Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium
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The study examined the effect of clonidine hydrochloride (10—9-10—5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10—5 М.
Key Wordsα2-adrenergic receptor clonidine action potential atrium; rat
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- 2.Gyires K, Zádori ZS, Török T, Mátyus P. alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions. Neurochem. Int. 2009;55(7):447-453.Google Scholar