Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 5, pp 680–685 | Cite as

Structure of Rat Testicles after Intravenous Injection of Nanosized Magnetite Particles

  • I. V. Mil’toEmail author
  • I. V. Sukhodolo
  • V. V. Ivanova
  • V. Yu. Usov

The structure of the testicles was studied in adult rats in 120 days after a single intravenous injection of chitosan-modified (magnetic nanospheres) and lipid-modified (magnetoliposomes) nanosized magnetite particles. Perls histochemical reaction detected in the testicular interstitial connective tissue the cells which absorbed and accumulated magnetite nanoparticles. The dynamics of spermatogenesis index and the count of Perls+ cells in the rat testicles were traced throughout the experiment. The studied modified nanosized magnetite particles did not penetrate through the blood—testicle barrier in rats.

Key Words

magnetite nanoparticles magnetic nanospheres magnetoliposomes testicles 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • I. V. Mil’to
    • 1
    Email author
  • I. V. Sukhodolo
    • 1
  • V. V. Ivanova
    • 1
  • V. Yu. Usov
    • 2
  1. 1.Department of Morphology and General Pathology, Siberian State Medical University, Ministry of Health of the Russian FederationTomskRussia
  2. 2.Department of X-Ray and Tomographic Diagnostic Methods, Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of SciencesTomskRussia

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