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Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 5, pp 676–679 | Cite as

Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging

  • V. A. Zuev
  • A. S. Dyatlova
  • N. S. Lin’kovaEmail author
  • T. V. Kvetnaya
BIOGERONTOLOGY
  • 9 Downloads

The expression of Aβ42, and τ-protein, and p16 and p53 proteins was analyzed in the buccal epithelium of elderly and senile patients with Alzheimer’s disease. We revealed enhanced synthesis of Alzheimer’s disease markers Aβ42 (by 15-30 times) and τ-protein (by 5 times) in comparison with the corresponding values in people without neurodegenerative pathology of the same age groups. In addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. These data suggest that complex analysis of the expression of Aβ42, τ-protein, p16, and p53 in the buccal epithelium is a promising method for in vivo diagnosis of Alzheimer’s disease and assessment of the rate of aging during the development of this pathology.

Key Words

buccal epithelium Alzheimer’s disease Aβ42 protein τ-protein aging 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. A. Zuev
    • 1
  • A. S. Dyatlova
    • 1
    • 2
  • N. S. Lin’kova
    • 1
    • 2
    Email author
  • T. V. Kvetnaya
    • 1
  1. 1.St. Petersburg Research Center Institute of Bioregulation and GerontologySt. PetersburgRussia
  2. 2.Peter the Great St. Petersburg Polytechnic UniversitySt. PetersburgRussia

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