Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 5, pp 646–650 | Cite as

Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin

  • E. B. Men’shchikovaEmail author
  • N. K. Zenkov
  • P. M. Kozhin
  • A. V. Chechushkov
  • A. V. Kovner
  • M. V. Khrapova
  • N. V. Kandalintseva
  • G. G. Martinovich

ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic antioxidant sodium 3-(3’-tert-butyl-4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a cumulative dose of 8 mg/kg were followed by inhibition of tumor growth by 49.5%. Combined treatment with TS-13 and doxorubicin suppressed the tumor growth by 55.4%. In contrast to doxorubicin, TS-13 inhibited NO generation by peritoneal macrophages. The results show the prospect of studying TS-13 in the context of overcoming drug-resistance of tumors.

Key Words

reactive oxygen metabolites grafted Leis lung carcinoma sulphur-containing phenolic antioxidant TS-13 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. B. Men’shchikova
    • 1
    Email author
  • N. K. Zenkov
    • 1
  • P. M. Kozhin
    • 1
  • A. V. Chechushkov
    • 1
  • A. V. Kovner
    • 1
  • M. V. Khrapova
    • 1
  • N. V. Kandalintseva
    • 2
  • G. G. Martinovich
    • 3
  1. 1.Federal Research Center of Fundamental and Translational MedicineNovosibirskRussia
  2. 2.Novosibirsk State Pedagogical UniversityNovosibirskRussia
  3. 3.Belarusian State UniversityMinskRepublic of Belarus

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