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Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 5, pp 613–616 | Cite as

Comparison of Reactivity of the Lipid Peroxidation–Antioxidant Defense System in Normal and Hypertensive Rats at Different Stages of Stress-Reaction

  • L. I. Kolesnikova
  • L. R. Kolesnikova
  • M. A. DarenskayaEmail author
  • L. V. Natyaganova
  • L. A. Grebenkina
  • L. I. Korytov
  • S. I. Kolesnikov
Article
  • 4 Downloads

We compared changes in the parameters of LPO—antioxidant defense system at various stages of the stress response in mature male ISIAH rats (hereditary stress-induced arterial hypertension) and WAG rats in 3 h (stage of anxiety) and 7 days (resistance stage) after a 3-h single immobilization in the supine position. It was found that post-stress reactivity of the nonspecific stress-limiting LPO system is different in normotensive and hypertensive rats. ISIAH rats, irrespective of the stage of the stress-reaction, demonstrated more intense LPO reactions (accumulation of TBA-reactive products) and reduced antioxidant defense parameters (low content of lipid-soluble vitamins, increased oxidized glutathione content) in comparison with the corresponding parameters in WAG rats.

Key Words

arterial hypertension lipid peroxidation antioxidant defense immobilization stress 

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. I. Kolesnikova
    • 1
  • L. R. Kolesnikova
    • 1
    • 2
  • M. A. Darenskaya
    • 1
    Email author
  • L. V. Natyaganova
    • 1
  • L. A. Grebenkina
    • 1
  • L. I. Korytov
    • 2
  • S. I. Kolesnikov
    • 1
    • 3
  1. 1.Research Center for Family Health and Human Reproduction ProblemsIrkutskRussia
  2. 2.Irkutsk State Medical UniversityMinistry of Health of the Russian FederationIrkutskRussia
  3. 3.M. V. Lomonosov Moscow State UniversityMoscowRussia

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