Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 5, pp 606–609 | Cite as

Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis

  • О. А. SafonovaEmail author
  • T. N. Popova
  • T. N. Shestakova

We studied the effect of 4-methyl-phenyl biguanide, a substance chosen by PASS software (Prediction of Activity Spectra for Substance), on oxidative status and activity of oxidation metabolism enzymes participating in limitation free radical processes (aconitate hydratase, glucose-6-phosphate dehydrogenase, and NADP-isocitrate dehydrogenase) in the heart and blood serum of rats with cardiovascular pathology developing against the background of experimental rheumatoid arthritis. Activity of cardiomyocyte cytolysis markers in rat blood serum was also measured. Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes.

Key Words

4-methyl-phenyl biguanide oxidative stress aconitate hydratase glucose-6-phosphate dehydrogenase NADP-isocitrate dehydrogenase 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • О. А. Safonova
    • 1
    Email author
  • T. N. Popova
    • 1
  • T. N. Shestakova
    • 1
  1. 1.Department of Medical Biochemistry and MicrobiologyVoronezh State UniversityVoronezhRussia

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