Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 4, pp 466–468 | Cite as

Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation

  • L. F. Zainullina
  • T. V. Ivanova
  • R. U. Ostrovskaya
  • T. A. Gudasheva
  • Yu. V. VakhitovaEmail author
  • S. B. Seredenin

Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity. The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. These data suggest that Noopept does not stimulate cell growth.

Key Words

Pro-Gly substituted dipeptides Noopept proliferation cell cycle Ki-67 


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. F. Zainullina
    • 1
  • T. V. Ivanova
    • 2
  • R. U. Ostrovskaya
    • 1
  • T. A. Gudasheva
    • 1
  • Yu. V. Vakhitova
    • 1
    Email author
  • S. B. Seredenin
    • 1
  1. 1.V. V. Zakusov Research Institute of PharmacologyMoscowRussia
  2. 2.Institute of Biochemistry and Genetics, Ufa Federal Research Center of Russian Academy of SciencesUfaRussia

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