Bulletin of Experimental Biology and Medicine

, Volume 166, Issue 3, pp 313–316 | Cite as

Pulmonary Microcirculation in Experimental Model of Pulmonary Thromboembolism under Conditions of α-Adrenoceptor Blockade

  • V. I. Evlakhov
  • I. Z. Poyassov
  • V. I. Ovsyannikov

Changes in the pulmonary microcirculation in isolated perfused rabbit lungs during modeling of pulmonary thromboembolism were studied in control animals and against the background of α-adrenoceptors blockade with phentolamine. Intravenous injection of emboli to control animals was followed by an increase in pressure in the pulmonary artery, mean capillary hydrostatic pressure, capillary filtration coefficient, pulmonary vascular resistance, as well as precapillary and postcapillary resistances. Against the background of α-adrenoceptor blockade, the increase in most parameters was less pronounced than in control animals, while capillary filtration coefficient increased more drastically. Thus, adrenergic mechanisms are involved in the constrictor reactions of both arterial and venous pulmonary vessels under conditions of pulmonary thromboembolism.

Key Words

pulmonary thromboembolism isolated lungs capillary filtration coefficient pulmonary veins α-adrenoceptors 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • V. I. Evlakhov
    • 1
  • I. Z. Poyassov
    • 1
  • V. I. Ovsyannikov
    • 1
  1. 1.Department of Physiology of the Visceral SystemInstitute of Experimental MedicineSt. PetersburgRussia

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