Bulletin of Experimental Biology and Medicine

, Volume 165, Issue 3, pp 347–350 | Cite as

The Effect of Dihydroquercetin on Catalytic Activity of Iron (II) Ions in the Fenton Reaction

  • I. V. Babenkova
  • A. N. Osipov
  • Yu. O. TeselkinEmail author

Dihydroquercetin is a natural flavonoid with antioxidant properties that are determined by its ability to scavenge free radicals and chelate transition metal ions. Chemiluminescent studies showed that iron (II) ions in complex with dihydroquercetin are inactive and cannot catalyze decomposition of hydrogen peroxide (Fenton reaction).

Key Words

dihydroquercetin taxifolin chelation of iron ions Fenton reaction chemiluminescence 


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  1. 1.
    Plotnikov MB, Tyukavkina NA, Plotnikova TM. Diquertin-Based Drugs. Tomsk, 2005. Russian.Google Scholar
  2. 2.
    Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 1997;22(5):749-760.CrossRefPubMedGoogle Scholar
  3. 3.
    Cheng Z, Yan G, Li Y, Chang W. Determination of antioxidant activity of phenolic antioxidants in a Fenton-type reaction system by chemiluminescence assay. Anal. Bioanal. Chem. 2003;375(3):376-380.CrossRefPubMedGoogle Scholar
  4. 4.
    Chobot V, Hadacek F. Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin. Redox Rep. 2011;16(6):242-247.CrossRefPubMedGoogle Scholar
  5. 5.
    Gammella E, Recalcati S, Cairo G. Dual role of ROS as signal and stress agents: iron tips the balance in favor of toxic effects. Oxid. Med. Cell. Longev. 2016;2016:8629024. doi: Scholar
  6. 6.
    Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011;283(2-3):65-87.CrossRefPubMedGoogle Scholar
  7. 7.
    Klebanov GI, Teselkin Yu O, Babenkova IV, Lyubitsky OB, Rebrova O Yu, Boldyrev AA, Vladimirov Yu A. Effect of carnosine and its components on free-radical reactions. Membr. Cell Biol. 1998;12(1):89-99.PubMedGoogle Scholar
  8. 8.
    Pietta PG. Flavonoids as antioxidants. J. Nat. Prod. 2000; 63(7):1035-1042.CrossRefPubMedGoogle Scholar
  9. 9.
    Shubina VS, Shatalin YV. Antioxidant and iron-chelating properties of taxifolin and its condensation product with glyoxylic acid. J. Food Sci. Technol. 2017;54(6):1467-1475.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Stepuro AI, Adamchuk RI, Oparin AY, Stepuro II. Thiamine inhibits formation of dityrosine, a specific marker of oxidative injury, in reactions catalyzed by oxoferryl forms of hemoglobin. Biochemistry (Mosc). 2008;73(9):1031-1041.CrossRefPubMedGoogle Scholar
  11. 11.
    Teixeira S, Siquet C, Alves C, Boal I, Marques MP, Borges F, Lima JL, Reis S. Structure-property studies on the antioxidant activity of flavonoids present in diet. Free Radic. Biol. Med. 2005;39(8):1099-1108.CrossRefPubMedGoogle Scholar
  12. 12.
    Tian B, Sun Z, Xu Z, Hua Y. Chemiluminescence analysis of the prooxidant and antioxidant effects of epigallocatechin-3-gallate. Asia Pac. J. Clin. Nutr. 2007;16(Suppl 1):153-157.PubMedGoogle Scholar
  13. 13.
    Topal F, Nar M, Gocer H, Kalin P, Kocyigit UM, Gülçin İ, Alwasel SH. Antioxidant activity of taxifolin: an activity-structure relationship. J. Enzyme Inhib. Med. Chem. 2016;31(4):674-683.CrossRefPubMedGoogle Scholar
  14. 14.
    Weidmann AE. Dihydroquercetin: more than just an impurity? Eur. J. Pharmacol. 2012;684(1-3):19-26.CrossRefPubMedGoogle Scholar
  15. 15.
    Yakutova ESh, Dremina YeS, Yevgina SA, Osipov AN, Sharov VS, Panasenko OM, Vladimirov YuA. Formation of free radicals on interaction of hypochlorite with iron (II) ions. Biophysics. 1994;39(2):241-245.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • I. V. Babenkova
    • 1
  • A. N. Osipov
    • 1
  • Yu. O. Teselkin
    • 1
    Email author
  1. 1.Department of Medical BiophysicsN. I. Pirogov Russian National Research Medical UniversityMoscowRussia

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