Bulletin of Experimental Biology and Medicine

, Volume 165, Issue 3, pp 340–343 | Cite as

Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia

  • O. G. BernikovaEmail author
  • K. A. Sedova
  • S. N. Kharin
  • Ya. E. Azarov

The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.

Key Words

ischemia predictors ventricular arrhythmias echinochrome analog U-441 cats 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • O. G. Bernikova
    • 1
    • 2
    Email author
  • K. A. Sedova
    • 1
    • 4
  • S. N. Kharin
    • 1
    • 3
  • Ya. E. Azarov
    • 1
    • 3
  1. 1.Institute of Physiology, Komi Science CenterUral Division of Russian Academy of SciencesSyktyvkarRussia
  2. 2.Department of TherapyMedical Institute of Pitirim Sorokin Syktyvkar State UniversitySyktyvkarRussia
  3. 3.Department of PhysiologyMedical Institute of Pitirim Sorokin Syktyvkar State UniversitySyktyvkarRussia
  4. 4.Department of Biomedical Technology, Faculty of Biomedical EngineeringCzech Technical UniversityPragueCzech Republic

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