Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia
The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.
Key Wordsischemia predictors ventricular arrhythmias echinochrome analog U-441 cats
Unable to display preview. Download preview PDF.
- 1.Buimov GA, Maksimov IV, Perchatkin VA, Repin AN, Afanas’ev SA, Markov VA, Karpov RS. The effect of bioantioxidant histochrome on myocardial injury during reperfusion therapy in patients with myocardial infarction. Ter. Arkh. 2002;74(8):12-16. Russian.Google Scholar
- 2.Ajijola OA, Lux RL, Khahera A, Kwon O, Aliotta E, Ennis DB, Fishbein MC, Ardell JL, Shivkumar K. Sympathetic modulation of electrical activation in normal and infracted myocardium: implications for arrhythmogenesis. Am. J. Physiol. Heart Circ. Physiol. 2017;312(3):H608-H621.CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Sedova KA, Bernikova OG, Goshka SL, Pokhilo ND, Atopkina LN, Shmakov DN, Kharin SN. Effects of an antioxidant agent on alterations of ventricular repolarization in a coronary artery occlusion-reperfusion experimental model. Exp. Clin. Cardiol. 2013:1-6.Google Scholar