Evaluation of DNA Damage in Experimental Preeclampsia by Comet Assay
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Experimental preeclampsia induced by substitution of drinking water with 1.8% NaCl during pregnancy was associated with an increase in the level of DNA damage in fetal brain and placenta measured by DNA comet assay by 35.7 and 27.8 times, respectively, in comparison with physiological pregnancy.
Key Wordsexperimental preeclampsia DNA damage DNA comet assay
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- 1.Zabrodina VV, Shreder ED, Shreder OV, Durnev AD, Seredenin SB. Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes. Bull. Exp. Biol. Med. 2015;159(6):757-760.Google Scholar
- 2.Ivanova LB, Karamysheva VI, Perfilova VN, Tiurenkov IN. The effect of GABA-derivatives on endothelial function in rats with experimental preeclampsia. Problemy Reproductsii. 2012;(1):28-30. Russian.Google Scholar
- 3.Tyurenkov IN, Perfilova VN, Lashchenova LI, Zhakupova GA, Lebedeva SA. Analysis of mental functions of the offspring from rats with experimental preeclampsia during postnatal ontogeny. Zh. Vyssh. Nervn. Deyat. 2016;66(4):499-510. Russian.Google Scholar
- 5.Tyurenkov IN, Perfilova VN, Popova TA, Karamysheva VI, Reznikova LB, Prokof’ev II, Mokrousov IS, Grindin EI, Mikhailova LI, Berestovitskaya VM, Vasil’eva OS. Effect of GABA Derivative – RSMU-151 on the Development of Oxidative Stress in Rats with Experimental Gestosis. Eksp. Klin. Farmakol. 2013;76(12):11-14. Russian.Google Scholar