Bulletin of Experimental Biology and Medicine

, Volume 163, Issue 6, pp 772–776 | Cite as

Role of LIF Cytokine and CD34 Angiogenesis Marker in Non-Developing Pregnancy

  • E. S. Popravka
  • A. S. Dyatlova
  • N. S. Lin’kova
  • Yu. S. Krylova
  • V. O. Polyakova
  • I. M. Kvetnoi

The expression of cytokine LIF (leukemia inhibiting factor) in the endometrium of women of young reproductive age with non-developing pregnancy of unknown genesis is higher than in older women and women with infection-related miscarriages by 1.26 and 1.43 times, respectively. The expression of angiogenesis marker CD34 in the endometrium of young women with non-developing pregnancy of unknown origin is 1.59 times higher and in case of endometrial inflammation 1.31 times higher than in women of the older reproductive age with the same disease. Correlation between the endometrial expression of LIF and CD34 is detected in women of the younger reproductive age with non-developing pregnancy of unknown etiology. The expression of LIF and CD34 can be used for endometrial function evaluation in women of different age with first trimester non-developing pregnancy.

Key Words

LIF CD34 gravidary endometrium non-developing pregnancy 


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • E. S. Popravka
    • 1
  • A. S. Dyatlova
    • 1
  • N. S. Lin’kova
    • 1
    • 3
  • Yu. S. Krylova
    • 2
  • V. O. Polyakova
    • 2
    • 4
  • I. M. Kvetnoi
    • 2
  1. 1.Medical Physics Department, Institute of Physics, Nanotechnologies, and TelecommunicationsPeter the Great St. Petersburg Polytechnic UniversitySt. PetersburgRussia
  2. 2.Pathomorphology DepartmentD. O. Ott Research Institute of Obstetrics, Gynecology, and ReproductologySt. PetersburgRussia
  3. 3.Department of BiogerontologySt. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia
  4. 4.Department of General Physiology, Soil Biology FacultySt. Petersburg State UniversitySt. PetersburgRussia

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