Skip to main content

Advertisement

Log in

Biodistribution of Viscumin after Subcutaneous Injection to Mice and In Vitro Modeling of Endoplasmic Reticulum Stress

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Viscumin (mistletoe lectin I, MLI) in concentrations of 10—11-10—7 M causes endoplasmic reticulum stress and triggers unfolded protein response, a modulator of antitumor immunity, in target cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Krainova NA, Khaustova NA, Makeeva DS, Fedotov NN, Gudim EA, Riabenko EA, Shkurnikov MYu, Galatenko VV, Sakharov DA, Maltseva DV. Evaluation of candidate reference genes for normalization of RT-PCR data with HeLa cells. Biotekhnologiya. 2013(1):42-50. Russian.

    Google Scholar 

  2. Khutornenko AA, Gerasimov VM, Sakharov DA. Preparation of viscumin-ferromagnetic particles conjugate and study of its internalization by human glioblastoma A172 cells. Bull. Exp. Biol. Med. 2015;160(12):823-826.

    Google Scholar 

  3. Aaes TL, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, Delrue I, Taminau J, Wiernicki B, De Groote P, Garg AD, Leybaert L, Grooten J, Bertrand MJ, Agostinis P, Berx G, Declercq W, Vandenabeele P, Krysko DV. Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity. Cell Rep. 2016;15(2):274-287.

    Article  CAS  PubMed  Google Scholar 

  4. Agapov II, Tonevitsky AG, Maluchenko NV, Moisenovich MM, Bulah YS, Kirpichnikov MP. Mistletoe lectin A-chain unfolds during the intracellular transport. FEBS Lett. 1999;464(1-2):63-66.

    Article  CAS  PubMed  Google Scholar 

  5. Agapov II, Tonevitsky AG, Moysenovich MM, Maluchenko NV, Weyhenmeyer R, Kirpichnikov MP. Mistletoe lectin dissociates into catalytic and binding subunits before translocation across the membrane to the cytoplasm. FEBS Lett. 1999;452(3):211-214.

    Article  CAS  PubMed  Google Scholar 

  6. Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response in immunity and inflammation. Nat. Rev. Immunol. 2016;16(8):469-484.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Maltseva DV, Khaustova NA, Fedotov NN, Matveeva EO, Lebedev AE, Shkurnikov MU, Galatenko VV, Schumacher U, Tonevitsky AG. High-throughput identification of reference genes for research and clinical RT-qPCR analysis of breast cancer samples. J. Clin. Bioinforma. 2013;3(1):13. doi: https://doi.org/10.1186/2043-9113-3-13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Manevich EM, Tonevitsky AG, Bergelson LD. The binding of the B-chain of ricin to Burkitt lymphoma cells. FEBS Lett. 1986;194(2):313-316.

    Article  CAS  PubMed  Google Scholar 

  9. Moisenovich M, Tonevitsky A, Agapov I, Niwa H, Schewe H, Bereiter-Hahn J. Differences in endocytosis and intracellular sorting of ricin and viscumin in 3T3 cells. Eur. J. Cell Biol. 2002;81(10):529-538.

    Article  CAS  Google Scholar 

  10. Moisenovich M, Tonevitsky A, Maljuchenko N, Kozlovskaya N, Agapov I, Volknandt W, Bereiter-Hahn J. Endosomal ricin transport: involvement of Rab4-and Rab5-positive compartments. Histochem. Cell Biol. 2004;121(6):429-439.

    Article  CAS  PubMed  Google Scholar 

  11. Sweeney EC, Tonevitsky AG, Palmer RA, Niwa H, Pfueller U, Eck J, Lentzen H, Agapov II, Kirpichnikov MP. Mistletoe lectin I forms a double trefoil structure. FEBS Lett. 1998;431(3):367-370.

    Article  CAS  PubMed  Google Scholar 

  12. Schumacher U, Pfüller U. From Berlin and Witten to Southampton and Hamburg: 25 Years of Mistletoe Research Cooperation. Mistletoe: From Mythology to Evidence-Based Medicine. Zänker KS, Kaveri SV, eds. Basel, 2015. Vol. 4. P. 39-47.

  13. Thies A, Dautel P, Meyer A, Pfüller U, Schumacher U. Lowdose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model. Br. J. Cancer. 2008;98(1):106-112.

    Article  CAS  PubMed  Google Scholar 

  14. Tonevitsky AG, Agapov II, Shamshiev AT, Temyakov DE, Pohl P, Kirpichnikov MP. Immunotoxins containing A-chain of mistletoe lectin I are more active than immunotoxins with ricin A-chain. FEBS Lett. 1996;392(2):166-168.

    Article  CAS  PubMed  Google Scholar 

  15. Tonevitsky AG, Zhukova OS, Mirimanova NV, Omelyanenko VG, Timofeeva NV, Bergelson LD. Effect of gangliosides on binding, internalization and cytotoxic activity of ricin. FEBS Lett. 1990;264(2):249-252.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to D. V. Maltseva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 4, pp. 448-453, April, 2017

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maltseva, D.V., Krainova, N.A., Khaustova, N.A. et al. Biodistribution of Viscumin after Subcutaneous Injection to Mice and In Vitro Modeling of Endoplasmic Reticulum Stress. Bull Exp Biol Med 163, 451–455 (2017). https://doi.org/10.1007/s10517-017-3826-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3826-7

Key Words

Navigation