Bulletin of Experimental Biology and Medicine

, Volume 163, Issue 3, pp 293–295 | Cite as

Effect of Chronic Administration of Obestatin and Its Fragment FNAP-NH2 on Behavioral Activity and Nociceptive Threshold in Rats with Normal and Excess Body Weight

  • E. E. Khirazova
  • E. S. Motorykina
  • M. V. Maslova
  • A. S. Maklakova
  • A. V. Graf
  • N. A. Sokolova
  • A. A. Kamenskii
PHYSIOLOGY
  • 29 Downloads

The effects of chronic intranasal administration of 300 nmol/kg obestatin and its fragment FNAP-NH2 on behavioral activity and nociceptive threshold were examined in male Wistar rats with normal body weight or alimentary obesity. In normal rats, obestatin produced no effect on behavior and nociception, whereas FNAP-NH2 fragment enhanced risk-taking behavior. Rats with excess body weight demonstrated less pronounced risk-taking behavior and elevated nociceptive threshold in comparison with normal animals, but these differences were abolished by chronic administration of FNAP-NH2.

Key Words

excess body weight alimentary obesity anxiety nociceptive threshold obestatin 

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References

  1. 1.
    Motorykina ES, Khirazova EE, Maslova MV, Maklakova AS, Graf AV, Bayzhymanov AA, Kurko OD, Zamyatina LA, Andreyeva LA, Sokolova NA, Myasoyedov NF, Kamenskii AA. Changes in feeding and drinking motivations and glucose content in male rats after single or chronic administration of obestatin or its fragment (1-4). Dokl. Biol. Sci. 2015;460:1-4.CrossRefPubMedGoogle Scholar
  2. 2.
    Khirazova EE, Bayzhumanov AA, Motorykina ES, Devyatov AA, Maslova MV, Graf AV, Sokolova NA, Golubeva MG, Kamenskii AA. Antioxidant defense system after single and chronic administration of obestatin and its fragment (1-4) to normal and overweight male rats. Bull. Exp. Biol. Med. 2015;159(1):38-40.CrossRefPubMedGoogle Scholar
  3. 3.
    Khirazova EE, Maslova MV, Motorykina ES, Frid DA, Graf AV, Maklakova AS, Sokolova NA, Kamenskii AA. Effects of single intranasal administration of obestatin fragments on the body weight and feeding and drinking behaviors. Dokl. Biol. Sci. 2013;453:336-337.CrossRefPubMedGoogle Scholar
  4. 4.
    Ataka K, Inui A, Asakawa A, Kato I, Fujimiya M. Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2008;294(5):G1210-G1218.CrossRefPubMedGoogle Scholar
  5. 5.
    Aydin S, Ozkan Y, Erman F, Gurates B, Kilic N, Colak R, Gundogan T, Catak Z, Bozkurt M, Akin O, Sen Y, Sahn I. Presence of obestatin in breast milk: relationship among obestatin, ghrelin, and leptin in lactating women. Nutrition. 2008;24(7-8):689-693.CrossRefPubMedGoogle Scholar
  6. 6.
    Bang AS, Soule SG, Yandle TG, Richards AM, Pemberton CJ. Characterisation of proghrelin peptides in mammalian tissue and plasma. J. Endocrinol. 2007;192(2):313-323.CrossRefPubMedGoogle Scholar
  7. 7.
    Chanoine JP, Wong AC, Barrios V. Obestatin, acylated and total ghrelin concentrations in the perinatal rat pancreas. Horm. Res. 2006;66(2):81-88.PubMedGoogle Scholar
  8. 8.
    Guneli E, Gumustekin M, Ates M. Possible involvement of ghrelin on pain threshold in obesity. Med. Hypotheses. 2010;74(3):452-454.CrossRefPubMedGoogle Scholar
  9. 9.
    Huda MS, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J, Wilding JP. Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal. Int. J. Obes. (Lond). 2008;32(1):129-135.CrossRefGoogle Scholar
  10. 10.
    Liptak N, Dochnal R, Csabafi K, Szakacs J, Szabo G. Obestatin prevents analgesic tolerance to morphine and reverses the effects of mild morphine withdrawal in mice. Regul. Pept. 2013;186:77-82.CrossRefPubMedGoogle Scholar
  11. 11.
    Price RC, Asenjo JF, Christou NV, Backman SB, Schweinhardt P. The role of excess subcutaneous fat in pain and sensory sensitivity in obesity. Eur. J. Pain. 2013;17(9):1316-1326.CrossRefPubMedGoogle Scholar
  12. 12.
    Rouwette T, Klemann K, Gaszner B, Scheffer GJ, Roubos EW, Scheenen WJ, Vissers K, Kozicz T. Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Neuroscience. 2011;183:15-24.CrossRefPubMedGoogle Scholar
  13. 13.
    Zamrazilova H, Hainer V, Sedlacková D, Papezova H, Kunesova M, Bellisle F, Hill M, Nedvídkova J. Plasma obestatin levels in normal weight, obese and anorectic women. Physiol. Res. 2008;57(Suppl 1):S49-S55.PubMedGoogle Scholar
  14. 14.
    Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelins’ effects on food intake. Science. 2005;310:996-999.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • E. E. Khirazova
    • 1
  • E. S. Motorykina
    • 1
  • M. V. Maslova
    • 1
  • A. S. Maklakova
    • 1
  • A. V. Graf
    • 1
    • 2
  • N. A. Sokolova
    • 1
  • A. A. Kamenskii
    • 1
  1. 1.Department of Human and Animal Physiology, Faculty of BiologyM. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Department of Nano-, Bio-, Information Technology, and Cognitive ScienceMoscow Institute of Physics and Technology (MIPT)MoscowRussia

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