Skip to main content
SpringerLink
Log in

Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Voronina TA, Seredenin SB. Nootropes (cognition enhancers) and neuroprotectors. Eksp. Klin. Farmakol. 2007;70(4):44-58. Russian.

    CAS  Google Scholar 

  2. Goldberg ED, Dygai AM, Zyuz’kov GN. Hypoxia and Blood System. Tomsk, 2006. Russian.

  3. Dygai AM, Zyuz’kov GN, Zhdanov VV, Udut VE, Khrichkova TYu, Miroshnichenko LA, Simanina EV, Stavrova LA. Methodical recommendations for studies of specific activity of agents for regenerative medicine. Manual for Preclinical Studies of New Pharmacological Substances. Part I, Mironov AN, ed. Moscow, 2012. P. 776-787. Russian.

  4. Zyuz’kov GN, Amosova EN, Chaikovskii AV, Miroshnichenko LA, Udut EV, Rybalkina OY, Zhdanov VV, Udut VV, Dygai AM, Zueva EP3. Antitumor effects of JAK3 inhibitor on the model of transplantable lewis lung carcinoma and mechanisms of their development. Bull. Exp. Biol. Med. 2016;161(3):367-370.

    Article  PubMed  Google Scholar 

  5. Zyuz’kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Polyakova TY, Stavrova LA, Udut VV, Minakova MY, Dygai AM. Involvement of JAK1, JAK2, and JAK3 in stimulation of functional activity of mesenchymal progenitor cells by fibroblast growth factor. Bull. Exp. Biol. Med. 2016;162(2):240-243.

    Article  PubMed  Google Scholar 

  6. Lukyanova LD, Kirova IuI, Sukoyan GV. Novel approaches to the understanding of signaling mechanisms of adaptation to hypoxia and its role in the systemic regulation of the body. Patogenez. 2011;9(3):4-14. Russian.

    Google Scholar 

  7. Curzon P, Zhang M, Radek RJ, Fox G.B. The behavioral assessment of sensorimotor processes in the mouse: acoustic startle, sensory gating, locomotor activity, rotarod, and beam walking. Methods of Behavior Analysis in Neuroscience. Buccafusco JJ, ed. Boca Raton; London; New York, 2009. P. 145-178.

  8. Dygai AM, Zyuz’kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Khrichkova TY, Simanina EV, Stavrova LA, Chaikovskiy AV, Markova TS, Minakova MY, Gol’dberg VE, Artamonov AV, Bekarev AA, Madonov PG, Kinsht DN, Gurto RV. Effect of hyaluronidase immobilized using electron-beam synthesis nanotechnology on sensitivity of progenitor cells to regulatory factors. Bull. Exp. Biol. Med. 2011;151(1):150-153.

    Article  CAS  PubMed  Google Scholar 

  9. Dygai AM, Zyuz’kov GN, Zhdanov VV, Madonov PG, Udut EV, Miroshnichenko LA, Khrichkova TY, Simanina EV, Stavrova LA, Artamonov AV, Bekarev AA, Kinsht DN, Chaikovskiy AV, Markova TS, Gurto RV. Pharmacological properties of granulocytic colony-stimulating factor pegylated using electron beam synthesis nanotechnologies. Bull. Exp. Biol. Med. 2011;152(1):133-137.

    Article  CAS  PubMed  Google Scholar 

  10. Zyuz’kov GN, Chaikovskii AV, Ligacheva AA, Zhdanov VV, Udut EV, Danilets MG, Miroshnichenko LA, Simanina EV, Suslov NI, Losev EA, Trofimova ES, Povet’eva TN, Nesterova YV, Fomina TI, Minakova MY, Dygai AM. Role of receptors to fibroblast growth factor (FGF) on mesenchymal precursor cells in the realization of regenerative effects of alkaloid songorine. Bull. Exp. Biol. Med. 2014;157(1):146-149.

    Article  PubMed  Google Scholar 

  11. Zyuz’kov GN, Danilets MG, Ligacheva AA, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Chaikovskii AV, Trofimova ES, Minakova MY, Udut VV, Dygai AM. PI3K, MAPK EPK1/2 and p38 are involved in the realization of growth potentialof mesenchymal progenitor cells under the influence of basic fibroblast growthfactor. Bull. Exp. Biol. Med. 2014;157(4):436-439.

    Article  PubMed  Google Scholar 

  12. Zyuz’kov GN, Krapivin AV, Nesterova YV, Povetieva TN, Zhdanov VV, Suslov NI, Fomina TI, Udut EV, Miroshnichenko LA, Simanina EV, Semenov AA, Kravtsova SS, Dygai AM. Mechanisms of regeneratory effects of Baikal Aconite diterpene alkaloids. Bull. Exp. Biol. Med. 2012;153(6):846-850.

    PubMed  Google Scholar 

  13. Zyuz’kov GN, Zhdanov VV, Udut EV, Miroshnichenko LA, Khrichkova TY, Danilets MG, Simanina EV, Chaikovskii AV, Agafonov VI, Sherstoboev EY, Minakova MY, Burmina YV, Udut VV, Dygai AM. Role of JNK and contribution of p53 to the realization of the growth potential of mesenchymal precursor cells under the effect of fibroblast growth factor. Bull. Exp. Biol. Med. 2015;159(4):479-481.

    Article  PubMed  Google Scholar 

  14. Zyuz’kov GN, Danilets MG, Ligacheva AA, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Trofimova ES, Minakova MY, Chaikovskii AV, Agafonov VI, Dygai AM. Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro. Bull. Exp. Biol. Med. 2013;155(6):721-723.

    Article  PubMed  Google Scholar 

  15. Zyuz’kov GN, Losev EA, Chaikovskii AV, Suslov NI, Zhdanov VV, Udut EV, Miroshnichenko LA, Simanina EV, Polyakova TY, Povet’eva TN, Nesterova YV, Stavrova LA, Udut VV, Minakova MY, Dygai AM. Psychopharmacological effects of alkaloid Z77 under conditions of posthypoxic encephalopathy and mechanisms of their development. Bull. Exp. Biol. Med. 2016;161(1):45-49.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    G. N. Zyuz’kov, N. I. Suslov, T. N. Povet’eva, Yu. V. Nesterova, O. G. Afanas’eva, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, T. Yu. Polyakova, L. A. Stavrova, A. V. Chaikovskii, P. V. Kul’pin, V. V. Udut, A. M. Dygai & V. V. Zhdanov

  2. Laboratory for Physical Processes Modeling in Biology and Medicine, National Research Tomsk State University, Tomsk, Russia

    G. N. Zyuz’kov & V. V. Udut

Authors
  1. G. N. Zyuz’kov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. I. Suslov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. N. Povet’eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu. V. Nesterova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. G. Afanas’eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. V. Udut
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. A. Miroshnichenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. V. Simanina
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. T. Yu. Polyakova
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. L. A. Stavrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. V. Chaikovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. P. V. Kul’pin
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. V. V. Udut
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. A. M. Dygai
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. V. V. Zhdanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 1, pp. 23-27, January, 2017

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zyuz’kov, G.N., Suslov, N.I., Povet’eva, T.N. et al. Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development. Bull Exp Biol Med 163, 18–21 (2017). https://doi.org/10.1007/s10517-017-3727-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-017-3727-9

Key Words

Search

Navigation