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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 6, pp 773–776 | Cite as

Secretion of Thioredoxin Peroxidase Protein of Cat Liver Fluke Opisthorchis felineus during Modeling of Experimental Opisthorchiasis

  • V. A. Petrenko
  • M. Yu. PakharukovaEmail author
  • A. V. Kovner
  • M. N. L’vova
  • V. V. Lyakhovich
  • V. A. Mordvinov
MICROBIOLOGY AND IMMUNOLOGY

Mechanisms of thioredoxin peroxidase secretion by Opisthorchis felineus were studied in vivo and in vitro. Specific antibodies were obtained and used for western blotting and immunohistochemical detection in Syrian hamster model of opisthorchiasis. Secreted thioredoxin peroxidase protein was accumulated in the worm incubation medium under conditions of oxidative stress and in bile duct cells of hamsters with chronic opisthorchiasis.

Key Words

opisthorchiasis excretory-secretory product active oxygen species thioredoxin peroxidase cat liver fluke Opisthorchis felineus 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • V. A. Petrenko
    • 1
  • M. Yu. Pakharukova
    • 1
    • 2
    Email author
  • A. V. Kovner
    • 1
  • M. N. L’vova
    • 1
  • V. V. Lyakhovich
    • 2
  • V. A. Mordvinov
    • 1
    • 2
  1. 1.Federal Research Centre Institute of Cytology and Genetics of the Siberian Division of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Research Institute of Molecular Biology and BiophysicsNovosibirskRussia

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