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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 6, pp 734–737 | Cite as

Analysis of Gut Microbiota in Patients with Parkinson’s Disease

  • V. A. PetrovEmail author
  • I. V. Saltykova
  • I. A. Zhukova
  • V. M. Alifirova
  • N. G. Zhukova
  • Yu. B. Dorofeeva
  • A. V. Tyakht
  • B. A. Kovarsky
  • D. G. Alekseev
  • E. S. Kostryukova
  • Yu. S. Mironova
  • O. P. Izhboldina
  • M. A. Nikitina
  • T. V. Perevozchikova
  • E. A. Fait
  • V. V. Babenko
  • M. T. Vakhitova
  • V. M. Govorun
  • A. E. Sazonov
Article

Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.

Key Words

gut microbiota Parkinson’s disease 16S rRNA sequencing 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • V. A. Petrov
    • 1
    Email author
  • I. V. Saltykova
    • 1
  • I. A. Zhukova
    • 1
  • V. M. Alifirova
    • 1
  • N. G. Zhukova
    • 1
  • Yu. B. Dorofeeva
    • 1
  • A. V. Tyakht
    • 2
  • B. A. Kovarsky
    • 2
  • D. G. Alekseev
    • 2
  • E. S. Kostryukova
    • 2
  • Yu. S. Mironova
    • 1
  • O. P. Izhboldina
    • 1
  • M. A. Nikitina
    • 1
  • T. V. Perevozchikova
    • 1
  • E. A. Fait
    • 1
  • V. V. Babenko
    • 2
  • M. T. Vakhitova
    • 2
  • V. M. Govorun
    • 2
    • 3
  • A. E. Sazonov
    • 1
    • 4
  1. 1.Siberian State Medical University, Ministry of Health of the Russian FederationTomskRussia
  2. 2.Federal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyMoscowRussia
  3. 3.M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic ChemistryMoscowRussia
  4. 4.M. V. Lomonosov Moscow State UniversityMoscowRussia

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