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Bulletin of Experimental Biology and Medicine

, Volume 162, Issue 4, pp 441–444 | Cite as

Effects of Afobazole on Postnatal Development of Rat Offspring

  • L. I. Bugaeva
  • T. D. Denisova
  • S. A. Sergeeva
  • Yu. A. Morozova
  • I. V. Kharlamov
PHARMACOLOGY AND TOXICOLOGY

Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.

Key Words

Afobazole ontogenesis rat offspring physical development 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • L. I. Bugaeva
    • 1
  • T. D. Denisova
    • 1
  • S. A. Sergeeva
    • 1
  • Yu. A. Morozova
    • 1
  • I. V. Kharlamov
    • 1
  1. 1.Research Institute of PharmacologyVolgograd State Medical University, Ministry of Health of the Russian FederationVolgogradRussia

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