Bulletin of Experimental Biology and Medicine

, Volume 161, Issue 6, pp 788–791 | Cite as

Effects of Single Administration of Bupropion on Carboxypeptidase E Activity in Structures of Rat Brain

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Depression is associated with changes in the levels of some neurotransmitters in various brain structures. Being the key enzyme of peptide processing, carboxypeptidase E regulates their levels in various structures of the nervous system. Single injection of bupropion induced long-lasting changes in carboxypeptidase E activity in all brain structures. The decrease in enzyme activity observed in 12 and 24 h after bupropion injection confirmed the inhibiting effect of the drug on the hypothalamic–pituitary–adrenal axis. Activation of the enzyme in the medulla oblongata, hypothalamus, and hippocampus observed in 72 h after bupropion administration probably leads to enhanced synthesis and secretion of regulatory peptides (reduced during stress and depression) and stimulation of neurogenesis. Changes in enzyme activity can be a mechanism regulating the level of bioactive peptides involved in the pathogenesis of depression.

Key Words

depression carboxypeptidase E bupropion monoamines regulatory peptides 
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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • A. D. Kruchinina
    • 1
  • S. S. Gamzin
    • 1
  • M. T. Tengin
    • 1
  1. 1.Department of General Biology and BiochemistryPenza State UniversityPenzaRussia

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