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Bulletin of Experimental Biology and Medicine

, Volume 161, Issue 4, pp 501–504 | Cite as

Effect of Linagliptin on Structural Changes in the Kidney in Experimental Type 2 Diabetes Mellitus

  • Yu. S. Gavrilova
  • N. P. Bgatova
  • V. V. Klimontov
  • I. Yu. Ischenko
  • S. V. Michurina
  • N. E. Myakina
  • E. L. Zavyalov
PHARMACOLOGY AND TOXICOLOGY

Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on structural manifestations of diabetic nephropathy was studied in BKS.Cg-Dock7m+/+Leprdb/J mice (experimental model of type 2 diabetes mellitus). Linagliptin (10 mg/kg per day) or vehicle was administered by gavage over 8 weeks. Mesangial expansion, thickening of the basement membrane in glomerular capillaries and proximal tubules, and retraction of cytopodia were less pronounced in mice receiving linagliptin. The protective effect of linagliptin on the kidney structure was not associated with its hypoglycemic action.

Key Words

type 2 diabetes mellitus diabetic nephropathy linagliptin 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yu. S. Gavrilova
    • 1
  • N. P. Bgatova
    • 1
  • V. V. Klimontov
    • 1
  • I. Yu. Ischenko
    • 1
  • S. V. Michurina
    • 1
  • N. E. Myakina
    • 1
  • E. L. Zavyalov
    • 2
  1. 1.Research Institute of Clinical and Experimental LymphologyNovosibirskRussia
  2. 2.Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of SciencesNovosibirskRussia

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