Loss of Cell Differentiation in HPV-Associated Bladder Cancer
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Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, while mRNA of E6 and E7 oncogenes and E7 oncoprotein of HPV16 were observed in 13 specimens. HPV-positive bladder cancer was characterized by higher degree of cell anaplasia than HPV-negative cancer; in the primary bladder tumor, HPV was detected more often than in recurrent bladder cancer. These data attest to involvement of HPV16 in the genesis of bladder cancer. No correlations of HPV status of bladder tumor with patient’s sex, age, and invasion into the muscle layer were revealed.
Key Wordsbladder cancer human papillomavirus
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- 1.G. M. Volgareva, L. E. Zavalishina, D. A. Golovina, Yu. Yu. Andreyeva, V. D. Ermilova, N. L. Cheban, D. A. Kuevda, O. B. Trofimova, O. Yu. Shipulina, L. S. Pavlova, A. N. Petrov, V. B. Matveev, A. A. Shtil, and G. A. Frank, Detection of oncoprotein E7 HPV16 in the cancer and normal urinary bladder urothelium. Arkhiv Patol., 71, No. 1, 29–30 (2009).Google Scholar
- 2.G. M. Volgareva, L. E. Zavalishina, D. A. Golovina, Yu. Yu. Andreeva, V. D. Ermilova, O. B. Trofimova, D. A. Kuevda, O. Yu. Shipulina, V. A. Glazunova, Shuling Cheng, L. S. Pavlova, N. L. Cheban, V. B. Matveev, and G. A. Frank, Cellular Expression of INK4a Gene in Cells of Bladder Cancer Associated with Human Papilloma Virus-16. Bull. Exp. Biol. Med., 149, No. 2, 242–245 (2010).Google Scholar
- 3.G. M. Volgareva, L. E. Zavalishina, O. B. Trofimova, L. I. Korolenkova, A. V. Khachaturyan, Yu. Yu. Andreyeva, V. D. Ermilova, N. D. Cheban, D. A. Kuevda, O. Yu. Shipulina, V. A. Glazunova, D. A. Golovina, A. N. Petrov, V. B. Matveyev, and G. A. Frank, Are human papillomaviruses responsible for the occurrence of bladder cancer. Arkhiv Patol., 72, No. 4, 24–27 (2010).Google Scholar
- 5.D. G. Zaridze, Cancer Surveillance [in Russian], Moscow (2009).Google Scholar
- 6.Malignant Tumors in Russia in 2012 (Disease Incidence and Mortality), Eds. A. D. Karpin, V. V. Starinskogo, and G. V. Petrova [in Russian], Moscow (2014).Google Scholar
- 8.IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 90. Human Papillomaviruses, Lyon (2007).Google Scholar
- 9.IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 100B. Biological Agents. Lyon (2012).Google Scholar
- 12.C. Morrison, F. Catania, P. Wakely Jr, and G. J. Nuovo, Highly differentiated keratinizing squamous cell cancer of the cervix: a rare, locally aggressive tumor not associated with human papillomavirus or squamous intraepithelial lesions. Am. J. Surg. Pathol., 25, No. 10, 1310–1315 (2001).CrossRefPubMedGoogle Scholar
- 14.World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs, Eds. J. N. Eble, et al., Lyon (2004).Google Scholar