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Bulletin of Experimental Biology and Medicine

, Volume 160, Issue 3, pp 347–349 | Cite as

Short Peptides and Telomere Length Regulator Hormone Irisin

  • V. Kh. Khavinson
  • B. I. Kuznik
  • S. I. Tarnovskaya
  • N. S. Lin’kovaEmail author
Article

Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.

Key Words

irisin short peptides telomeres epigenetics 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • V. Kh. Khavinson
    • 1
    • 2
  • B. I. Kuznik
    • 3
  • S. I. Tarnovskaya
    • 2
    • 4
  • N. S. Lin’kova
    • 2
    • 4
    Email author
  1. 1.Russian Academy of SciencesI. P. Pavlov Institute of PhysiologyMoskvaRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia
  3. 3.Chita State Medical AcademyMinistry of Health of the Russian FederationChitaRussia
  4. 4.St. Petersburg State Polytechnological UniversitySt. PetersburgRussia

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