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Bulletin of Experimental Biology and Medicine

, Volume 159, Issue 5, pp 642–645 | Cite as

Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine

  • G. N. Zyuz’kovEmail author
  • V. V. Zhdanov
  • E. V. Udut
  • L. A. Miroshnichenko
  • A. V. Chaikovskii
  • E. V. Simanina
  • T. Yu. Polyakova
  • M. Yu. Minakova
  • V. V. Udut
  • T. G. Tolstikova
  • E. E. Shul’ts
  • L. A. Stavrova
  • Ya. V. Burmina
  • N. I. Suslov
  • A. M. Dygai
MICROBIOLOGY AND IMMUNOLOGY

The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.

Key Words

cAMP IKK alkaloids progenitor cells regenerative medicine 

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References

  1. 1.
    G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, et al., Bull. Exp. Biol. Med., 159, No. 1, 67-70 (2015).Google Scholar
  2. 2.
    G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, et al., Bull. Exp. Biol. Med., 158, No. 11, 572-575 (2014).Google Scholar
  3. 3.
    A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Bull. Exp. Biol. Med., 151, No. 1, 74-78 (2011).CrossRefPubMedGoogle Scholar
  4. 4.
    A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Bull. Exp. Biol. Med., 148, No. 1, 120-125 (2009).CrossRefPubMedGoogle Scholar
  5. 5.
    A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Stem Cell Rev., 9, No. 2, 140-147 (2013).CrossRefPubMedGoogle Scholar
  6. 6.
    O. I. Epstein, G. N. Zyuz’kov, N. V. Sotnikova, et al., Bull. Exp. Biol. Med., 140, No. 5, 598-602 (2005).CrossRefPubMedGoogle Scholar
  7. 7.
    E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, et al., Bull. Exp. Biol. Med., 143, No. 4, 548-551 (2007).CrossRefPubMedGoogle Scholar
  8. 8.
    E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, and V. V. Zhdanov, Bull. Exp. Biol. Med., 144, No. 6, 802-805 (2007).CrossRefPubMedGoogle Scholar
  9. 9.
    G. N. Zyuz’kov, A. V. Chaikovskii, A. A. Ligacheva, et al., Bull. Exp. Biol. Med., 157, No. 1, 146-149 (2014).CrossRefPubMedGoogle Scholar
  10. 10.
    G. N. Zyuz’kov, A. V. Krapivin, Yu. V. Nesterova, et al., Bull. Exp. Biol. Med., 153, No. 6, 847-851 (2012).CrossRefGoogle Scholar
  11. 11.
    G. N. Zyuz’kov, L. A. Gur’yantseva, E. V. Simanina, et al., Bull. Exp. Biol. Med., 143, No. 4, 535-538 (2007)CrossRefPubMedGoogle Scholar
  12. 12.
    G. N. Zyuz’kov, L. A. Gur’yantseva, N. I. Suslov, et al., Bull. Exp. Biol. Med., 134, No. 4, 325-328 (2002).CrossRefPubMedGoogle Scholar
  13. 13.
    G. N. Zyuz’kov, V. V. Zhdanov, M. G. Danilets, et al., Bull. Exp. Biol. Med., 157, No. 2, 224-227 (2014).CrossRefPubMedGoogle Scholar
  14. 14.
    G. N. Zyuz’kov, V. V. Zhdanov, A. M. Dygai, and E. D. Gol’dberg, Bull. Exp. Biol. Med., 144, No. 6, 840-845 (2007).CrossRefPubMedGoogle Scholar
  15. 15.
    G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, et al., Bull. Exp. Biol. Med., 155, No. 3, 350-353 (2013).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • G. N. Zyuz’kov
    • 1
    • 2
    Email author
  • V. V. Zhdanov
    • 1
  • E. V. Udut
    • 1
  • L. A. Miroshnichenko
    • 1
  • A. V. Chaikovskii
    • 1
  • E. V. Simanina
    • 1
  • T. Yu. Polyakova
    • 1
  • M. Yu. Minakova
    • 1
  • V. V. Udut
    • 1
    • 2
  • T. G. Tolstikova
    • 3
  • E. E. Shul’ts
    • 3
  • L. A. Stavrova
    • 1
  • Ya. V. Burmina
    • 1
  • N. I. Suslov
    • 1
  • A. M. Dygai
    • 1
  1. 1.E. D. Goldberg Research Institute of Pharmacology and Regenerative MedicineTomskRussian Federation
  2. 2.National Research Tomsk State UniversityTomskRussian Federation
  3. 3.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Division of the Russian Academy of SciencesNovosibirskRussia

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