Bulletin of Experimental Biology and Medicine

, Volume 159, Issue 4, pp 528–533 | Cite as

Intra-Arterial Administration of Multipotent Mesenchymal Stromal Cells Promotes Functional Recovery of the Brain After Traumatic Brain Injury

  • D. N. Silachev
  • E. Yu. Plotnikov
  • V. A. Babenko
  • T. I. Danilina
  • L. D. Zorov
  • I. B. Pevzner
  • D. B. Zorov
  • G. T. Sukhikh
CELL TECHNOLOGIES IN BIOLOGY AND MEDICINE

We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury.

Key Words

traumatic brain injury stem cells migration sensorimotor deficit 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • D. N. Silachev
    • 1
  • E. Yu. Plotnikov
    • 1
  • V. A. Babenko
    • 2
    • 5
  • T. I. Danilina
    • 4
  • L. D. Zorov
    • 3
  • I. B. Pevzner
    • 1
  • D. B. Zorov
    • 1
  • G. T. Sukhikh
    • 5
  1. 1.A. N. Belozersky Institute of Physicochemical BiologyMoscowRussia
  2. 2.Faculty and Bioengineering and BioinformaticsMoscowRussia
  3. 3.International Laser Research CenterMoscowRussia
  4. 4.Biological FacultyM. V. Lomonosov Moscow State UniversityMoscowRussia
  5. 5.V. I. Kulakov Research Center of Obstetrics, Gynecology, and PerinatologyMinistry of Health of the Russian FederationMoscowRussia

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