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Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine

  • G. N. Zyuz’kovEmail author
  • V. V. Zhdanov
  • L. A. Miroshnichenko
  • E. V. Udut
  • A. V. Chaikovskii
  • E. V. Simanina
  • M. G. Danilets
  • M. Yu. Minakova
  • V. V. Udut
  • T. G. Tolstikova
  • E. E. Shults
  • L. A. Stavrova
  • Ya. V. Burmina
  • A. M. Dygai
Article

We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.

Key Words

PI3K МАРK alkaloids progenitor cells regenerative medicine 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • G. N. Zyuz’kov
    • 1
    • 2
    Email author
  • V. V. Zhdanov
    • 1
  • L. A. Miroshnichenko
    • 1
  • E. V. Udut
    • 1
  • A. V. Chaikovskii
    • 1
  • E. V. Simanina
    • 1
  • M. G. Danilets
    • 1
  • M. Yu. Minakova
    • 1
  • V. V. Udut
    • 1
    • 2
  • T. G. Tolstikova
    • 3
  • E. E. Shults
    • 3
  • L. A. Stavrova
    • 1
  • Ya. V. Burmina
    • 1
  • A. M. Dygai
    • 1
  1. 1.E. D. Goldberg Research Institute of Pharmacology and Regenerative MedicineTomskRussia
  2. 2.National Research Tomsk State UniversityTomskRussia
  3. 3.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Division of the Russian Academy of SciencesNovosibirskRussia

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