Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats

  • E. E. Khirazova
  • A. A. Bayzhumanov
  • E. S. Motorykina
  • A. A. Devyatov
  • M. V. Maslova
  • A. V. Graf
  • N. A. Sokolova
  • M. G. Golubeva
  • A. A. Kamenskii
Pharmacology and Toxicology

We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.

Key Words

obestatin antioxidant defense system overweight 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • E. E. Khirazova
    • 1
  • A. A. Bayzhumanov
    • 2
  • E. S. Motorykina
    • 1
  • A. A. Devyatov
    • 1
  • M. V. Maslova
    • 1
  • A. V. Graf
    • 1
  • N. A. Sokolova
    • 1
  • M. G. Golubeva
    • 1
  • A. A. Kamenskii
    • 1
  1. 1.Department of Human and Animal PhysiologyM. V. Lomonosov State Moscow UniversityMoscowRussia
  2. 2.Department of Biophysics, Biological FacultyM. V. Lomonosov State Moscow UniversityMoscowRussia

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