Different Myocardial Sensitivity in Newborn and Mature Rats to Selective Stimulation of M3 Cholinoreceptors

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The effects of selective activation of subtype 3 muscarinic (M3) receptors on electrical activity of isolated preparations of the atrial and ventricular myocardium of the newborn and 4-month-old rats were examined. Application of muscarinic receptor agonist pilocarpine (10–5 M) in preparations with M2 cholinoreceptors blocked by selective antagonist methoctramine (10–7 M) decreased the duration of action potentials in the atrial and ventricular myocardium. Selective blocker of M3 cholinoreceptors 4-DAMP (10–8 M) prevented this effect. While stimulation of ventricular M3 cholinoreceptors with pilocarpine was significantly stronger in newborn pups than in mature rats, similar stimulation of atrial receptors revealed no significant difference in both groups.

Key Words

cardiac muscarinic receptors acetylcholine atrium ventricle action potential 
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References

  1. 1.
    D. V. Abramochkin, M. A. Suris, A. A. Borodinova, et al., Neirokhimiya, 25, No. 1, 105-110 (2008).Google Scholar
  2. 2.
    D. V. Abramochkin, S. V. Tapilina, G. S. Sukhova et al., Pflügers Arch., 463, No. 4, 523-529 (2012).PubMedCrossRefGoogle Scholar
  3. 3.
    O. E. Brodde and M. C. Michel, Pharmacol. Rev., 51, No. 4, 651-689 (1999).PubMedGoogle Scholar
  4. 4.
    S. Dhein, C. J. Van Koppen, and O. Brodde, Pharmacol. Res., 44, No. 3, 161-182 (2001).PubMedCrossRefGoogle Scholar
  5. 5.
    P. Hang, J. Zhao, J. Qi, et al., Curr. Drug Targets, 14, No. 3, 372-377 (2013).PubMedGoogle Scholar
  6. 6.
    P. Z. Hang, J. Zhao, Y. P. Wang, et al., Naunyn Schmiedebergs Arch. Pharmacol., 380, No. 5, 443-450 (2009).PubMedCrossRefGoogle Scholar
  7. 7.
    H. Shi, H. Wang, B. Yang, et al., J. Biol. Chem., 279, No. 21, 21774-21778 (2004).PubMedCrossRefGoogle Scholar
  8. 8.
    H. Wang, Y. Lu, and Z. Wang, Auton. Autacoid Pharmacol., 27, No. 1, 1-11 (2007).PubMedCrossRefGoogle Scholar
  9. 9.
    H. Wang, H. Shi, Y. Li, et al., Br. J. Pharmacol., 126, No. 8, 1725-1734 (1999).PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    T. L. Zefirov, A. E. Gibina, M. A. Salman, et al., Bull. Exp. Biol. Med., 144, No. 2, 171-173 (2007).PubMedCrossRefGoogle Scholar
  11. 11.
    N. I. Ziyatdinova, A. M. Sergeeva, R. E. Dementieva, and T. L. Zefirov, Bull. Exp. Biol. Med., 154, No. 1, 1-2 (2012).PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Human and Animal PhysiologyM. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Department of PhysiologyN. I. Pirogov Russian National Research Medical UniversityMoscowRussia

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