Bulletin of Experimental Biology and Medicine

, Volume 158, Issue 6, pp 789–793 | Cite as

PT/Y Mice Are Sensitive to the Inhibitory Effect of o-Aminoazotoluene on Glucocorticoid Induction of Tyrosine Aminotransferase and Its Hepatocarcinogenic Effect

  • T. S. MorozkovaEmail author
  • L. A. Bogdanova
  • D. E. Semenov
  • N. A. Zhukova
  • N. A. Popova

PT/Y mice used for studies of the effects of mutagens are characterized by the absence of spontaneous tumors of the liver, but often develop these tumors in response to chronic oaminoazotoluene treatment. The level of glucocorticoid induction of adaptive hepatic enzyme tyrosine aminotransferase decreases by more than 70 % 24 h after acute injection of o-aminoazotoluene to these animals. These mice can serve as a model for studies of the relationship between the effect of carcinogens on the regulation of activity of adaptive hepatic enzymes and their capacity to induce the development of liver tumors.

Key Words

PT/Y mice o-aminoazotoluene hepatocarcinogenic effect 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • T. S. Morozkova
    • 1
    • 2
    Email author
  • L. A. Bogdanova
    • 1
  • D. E. Semenov
    • 1
  • N. A. Zhukova
    • 1
    • 2
  • N. A. Popova
    • 1
    • 3
  1. 1.Research Institute of Regional Pathology and PathomorphologySiberian Division of the Russian Academy of Medical SciencesNovosibirskRussia
  2. 2.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Division of the Russian Academy of SciencesNovosibirskRussia
  3. 3.Novosibirsk State UniversityNovosibirskRussia

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