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Bulletin of Experimental Biology and Medicine

, Volume 157, Issue 6, pp 715–717 | Cite as

Integral Indicator of Oxidative Stress in Human Blood

  • L. I. Kolesnikova
  • N. V. SemyonovaEmail author
  • L. A. Grebenkina
  • M. A. Darenskaya
  • L. V. Suturina
  • S. V. Gnusina
GENERAL PATHOLOGY AND PATHOPHYSIOLOGY

Here we performed individual evaluation of the oxidative stress index that serves as an integral criterion for the balance of LPO–antioxidant defense system in women with endocrine pathology (type 1 diabetes mellitus and infertility with hyperprolactinemia). The state of the LPO–antioxidant defense system was estimated from blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes, conjugated trienes, thiobarbituric acid-reactive substances, retinol, α-tocopherol, reduced and oxidized glutathione, and SOD activity. The use of this oxidative stress index allowed us to diagnose oxidative stress in female patients with endocrine pathology.

Key Words

oxidative stress index diabetes mellitus infertility 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • L. I. Kolesnikova
    • 1
  • N. V. Semyonova
    • 1
    Email author
  • L. A. Grebenkina
    • 1
  • M. A. Darenskaya
    • 1
  • L. V. Suturina
    • 1
  • S. V. Gnusina
    • 1
  1. 1.Research Center for Problems of Family Health and Human ReproductionSiberian Division of the Russian Academy of Medical SciencesIrkutskRussia

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