Changes in Thyroid Status of Rats after Prolonged Exposure to Low Dose Dichlorodiphenyltrichloroethane
- 119 Downloads
The effect of low dose dichlorodiphenyltrichloroethane (DDT), omnipresent ecotoxicant and endocrine disruptor, on the functioning of the endocrine system is an urgent problem. We studied the effect of low dose DDT on thyroid status in rats. Rats receiving DDT in a dose of 1.890±0.086 μg/kg for 6 weeks showed increased concentrations of thyroid hormones, particularly triiodothyronine, and reduced level of thyrotropin. Longer exposure reduced the production of thyroid hormones. The dynamics of thyroid status parameters during DDT treatment in a low dose was similar to changes observed during the development of hypothyroidism induced by iodine deficiency.
Keywordsthyroid hormones endocrine disruptors dichlorodiphenyltrichloroethane thyroid gland hypothyroidism
Unable to display preview. Download preview PDF.
- 1.Hygienic Requirements to Foodstuff Safety and Nutritive Value [in Russian], SanPin 22.214.171.1248-01.2008.Google Scholar
- 2.I. I. Dedov, G. A. Gerasimov, and N. Yu. Sviridenko, Iodine Defi ciency Diseases in the Russian Federation (Epidemiology, Diagnosis, and Prevention) [in Russian], Moscow (1999).Google Scholar
- 4.N. V. Yaglova and V. V. Yaglov, Vestn. Ross. Akad. Med. Nauk, No. 3, 56-61 (2012).Google Scholar