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Participation of PI3K, MAPK ERK1/2, and p38 in the Realization of Growth Potential of Mesenchymal Precursor Cells under In Vitro Conditions

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the role of intracellular signal molecules PI3K, MAPK ERK1/2, and p38 in the realization of the growth potential of mesenchymal progenitor elements. Under in vitro conditions, PI3K и ERK1/2 specifi c inhibitors reduced fi broblastic colony- and cluster-formation and considerably suppressed proliferative activity of mesenchymal precursors. Blocker of p38 and protein kinase B had no effect on the function of fi broblast CFU.

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Authors and Affiliations

  1. Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, E. S. Trofi mova, M. Yu. Minakova, A. V. Chaikovskii, V. I. Agafonov & A. M. Dygai

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  1. G. N. Zyuz’kov
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  2. M. G. Danilets
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  3. A. A. Ligacheva
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  4. V. V. Zhdanov
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  5. E. V. Udut
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  6. L. A. Miroshnichenko
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  7. E. V. Simanina
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  8. E. S. Trofi mova
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  9. M. Yu. Minakova
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  10. A. V. Chaikovskii
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  11. V. I. Agafonov
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  12. A. M. Dygai
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 206-209, October, 2013

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Zyuz’kov, G.N., Danilets, M.G., Ligacheva, A.A. et al. Participation of PI3K, MAPK ERK1/2, and p38 in the Realization of Growth Potential of Mesenchymal Precursor Cells under In Vitro Conditions. Bull Exp Biol Med 156, 556–559 (2014). https://doi.org/10.1007/s10517-014-2395-2

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  • DOI: https://doi.org/10.1007/s10517-014-2395-2

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