Cytokine Profile of Peripheral Blood in Rats with Various Behavioral Characteristics during Acute Emotional Stress
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The cytokine profile of peripheral blood plasma was studied in rats with various behavioral characteristics after acute emotional stress (1-hour immobilization with simultaneous electrocutaneous stimulation). Under basal conditions the concentrations of pro-inflammatory (IL-1α, IL-1β, IL-2, IFN-γ, and granulocyte-monocyte CSF) and anti-inflammatory cytokines (IL-4 and IL-10) in the blood of active animals were higher than in passive specimens. Acute stress was accompanied by a decrease in the level of plasma cytokines in behaviorally active rats. Stressed passive specimens were characterized by the accumulation of a pro-inflammatory cytokine IL-1β and anti-inflammatory cytokine IL-4 in the peripheral blood. The observed differences in the cytokine profile of the blood in behaviorally passive and active rats under basal conditions and after a negative emotiogenic exposure can be related to the specifics of immune reactions and metabolic processes in animals with different prognostic resistance to similar stress factors.
Keywords
emotional stress pro- and anti-inflammatory cytokines blood rats with various behavioral characteristicsPreview
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