Induction of S100B Gene Expression in Long-Term Potentiation in the Hippocampal CA1 Field Depends on Activity of NMDA Receptors
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The effects of NMDA receptor blocker MK-801 on the increase in S100B protein mRNA content induced by long-term posttetanic potentiation in the hippocampal sections were studied. The level of S100B mRNA after 30-min tetanization in the presence of 10 μM MK-801 constituted 132% of the basal level, which was significantly (226%) lower than the control level. Hence, gene expression, induced by long-term posttetanic potentiation, in the glial cells (similarly as in the neurons) depended significantly on NMDA receptors.
Key Wordslong-term potentiation CA1 S100B NMDA p53
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