Bulletin of Experimental Biology and Medicine

, Volume 154, Issue 2, pp 287–291 | Cite as

Expression of Antiangiogenic Factors in the Placental Structures in Pre-Eclampsia

  • A. I. Shchyogolev
  • E. A. Dubova
  • K. A. Pavlova
  • V. M. Lyapin
  • G. T. Sukhikh
Article

Comparative morphological study of the placentas was carried out in women with pregnancy aggravated by the development of pre-eclampsia. Immunohistochemical methods showed increased expression of endoglin (CD105) and VEGFR1 in all placental structures. The intensity of endoglin and VEGFR1 expression was maximum in the syncytiotrophoblast and extravillous cytotrophoblast cells in severe pre-eclampsia.

Key Words

pre-eclampsia placenta endoglin VEGFR1 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • A. I. Shchyogolev
    • 1
  • E. A. Dubova
    • 1
  • K. A. Pavlova
    • 1
  • V. M. Lyapin
    • 1
  • G. T. Sukhikh
    • 1
  1. 1.V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatologythe Ministry of Health and Social Development of the Russian FederationMoscowRussia

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