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Bulletin of Experimental Biology and Medicine

, Volume 153, Issue 5, pp 710–713 | Cite as

Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock

  • I. N. Tyurenkov
  • L. E. BorodkinaEmail author
  • V. V. Bagmetova
Article

New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing glutamate and glycine were signifi cantly more active than the initial substance.

Keywords

baclofen electroconvulsive shock maximum electroshock neuroprotective effect anticonvulsive effect 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • I. N. Tyurenkov
    • 1
  • L. E. Borodkina
    • 1
    Email author
  • V. V. Bagmetova
    • 1
  1. 1.Volgograd State Medical UniversityVolgogradRussia

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