Bulletin of Experimental Biology and Medicine

, Volume 153, Issue 2, pp 255–258 | Cite as

Molecular Cellular Mechanisms of Peptide Regulation of Melatonin Synthesis in Pinealocyte Culture

  • V. Kh. Khavinson
  • N. S. Linkova
  • I. M. Kvetnoy
  • T. V. Kvetnaia
  • V. O. Polyakova
  • H.-W. Korf
Biogerontology

The effects of epithalone and vilone peptides on the synthesis of melatonin and factors involved in this process, arylalkylamine-N-acetyltransferase (AANAT) enzyme and pCREB transcription protein, were studied in rat pinealocyte culture. Epithalone stimulated AANAT and pCREB synthesis and increased melatonin level in culture medium. Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.

Key Words

peptides pinealocytes melatonin signal molecules 

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • V. Kh. Khavinson
    • 1
    • 2
  • N. S. Linkova
    • 2
  • I. M. Kvetnoy
    • 2
  • T. V. Kvetnaia
    • 2
  • V. O. Polyakova
    • 2
  • H.-W. Korf
  1. 1.I. P. Pavlov Institute of Physiology, the Russian Academy of SciencesSt. PetersburgRussia
  2. 2.St. Petersburg Institute of Bioregulation and GerontologySt. PetersburgRussia

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