Dimebon Reduces the Levels of Aggregated Amyloidogenic Protein Forms in Detergent-Insoluble Fractions In Vivo
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Aggregation of proteins liable to assembling into fi brils with subsequent formation of amyloid incorporations is an important component in the pathogenesis of many neurodegenerative diseases. Dimebon, a Russian drug, reduces the content of detergent-insoluble fi brillar forms of synuclein, the main protein component of pathological incorporations in neurons of transgenic mouse strain used in the study.
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dimebon neurodegeneration synucleins transgenic animalsPreview
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References
- 1.S. O. Bachurin, A. A. Ustyugov, O. Peters, et al., Dokl. Ross. Akad. Nauk, Biochim. Biophys., 428, No. 2, 262-265 (2009).Google Scholar
- 2.V. L. Buchman, J. Adu, L. G. Pinõn, et al., Nat. Neurosci., 1, No. 2, 101-103 (1998).PubMedCrossRefGoogle Scholar
- 3.V. L. Buchman, H. J. Hunter, L. G. Pinõn, et al., J. Neurosci., 15, No. 18, 9335-9341 (1998).Google Scholar
- 4.R. S. Doody, S. I. Gavrilova, M. Sano, et al., Lancet, 372, 207-215 (2008).PubMedCrossRefGoogle Scholar
- 5.K. Kieburtz, M. P. McDermott, T. S. Voss, et al., Arch. Neurol., 67, No. 2, 154-160 (2010).PubMedCrossRefGoogle Scholar
- 6.P. T. Lansbury and H. A. Lashuel, Nature, 443, 774-779 (2006).PubMedCrossRefGoogle Scholar
- 7.N. Ninkina, O. Peters, S. Millership, et al., Hum. Mol. Genet., 18, No. 10, 1779-1794 (2009).PubMedCrossRefGoogle Scholar
- 8.D. M. Skovronsky, V. M. Lee, and J. Q. Trojanowski, Ann. Rev. Pathol., 1, 151-170 (2006).CrossRefGoogle Scholar
- 9.J. W. Steele, S. H. Kim, J. R. Cirrito, et al., Mol. Neurodegener., 4, 51 (2009).PubMedCrossRefGoogle Scholar
- 10.J. Wu, Q. Li, and I. Bezprozvanny, Ibid., 3, 15 (2008).Google Scholar
- 11.M. Yamashita, T. Nonaka, T. Arai, et al., FEBS Lett., 583, No. 14, 2419-2424 (2009).PubMedCrossRefGoogle Scholar
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