Antiviral Activity of Inonotus Obliquus Fungus Extract towards Infection Caused by Hepatitis C Virus in Cell Cultures

  • V. A. Shibnev
  • D. V. Mishin
  • T. M. Garaev
  • N. P. Finogenova
  • A. G. Botikov
  • P. G. Deryabin
Virology

Fractions of Inonotus obliquus fungus water extract exhibited a virucidal effect towards hepatitis C virus: it 100-fold reduced its infective properties within 10 min. The antiviral effects of fungus extracts manifested after preventive (24 h before infection) and therapeutic use (during infection of porcine embryo kidney cells). Moreover, the data indicate that the birch fungus extracts inhibit production of infective virus by porcine embryo kidney cells.

Key Words

virus hepatitis C cell cultures fungus extract fractions 

References

  1. 1.
    D. K. L’vov, E. I. Samokhvalov, S. Mishiro, et al., Vopr. Virusol., No. 4, 157–161 (1997).Google Scholar
  2. 2.
    P. G. Deryabin, S. O. Vyazov, E. I. Isaeva, et al., Ibid., No. 6, 254–258 (1997).Google Scholar
  3. 3.
    P. G. Deryabin and D. K. L’vov, Dokl. Rossiisk. Akad. Nauk, No. 5, 688–691 (1998).Google Scholar
  4. 4.
    L. Liang, Z. Zhang, and H. Wang, Int. J. Food Sci. Nutr., 60, Suppl. 2, 175–184 (2009).PubMedCrossRefGoogle Scholar
  5. 5.
    Q. Van, B. N. Nayak, M. Reimer, et al., J. Ethnopharmacol., 125, No. 3, 487–493 (2009).PubMedCrossRefGoogle Scholar
  6. 6.
    X. H. Zhong, L. B. Wang, and D. Z. Sun, Chin. J. Integr. Med., 17, No. 3, 218–223 (2011).PubMedCrossRefGoogle Scholar
  7. 7.
    D. P. Won, J. S. Lee, D. S. Kwon, et al., Mol. Cells, 31, No. 2, 165–173 (2011).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. A. Shibnev
    • 1
  • D. V. Mishin
    • 1
  • T. M. Garaev
    • 1
  • N. P. Finogenova
    • 1
  • A. G. Botikov
    • 1
  • P. G. Deryabin
    • 1
  1. 1.D. I. Ivanovsky Institute of VirologyMinistry of Health Care and Social Development of the Russian FederationMoscowRussia

Personalised recommendations