Bulletin of Experimental Biology and Medicine

, Volume 151, Issue 3, pp 356–358 | Cite as

Immune Response during Activation of Pre- and Postsynaptic Serotonin 5-HT1A Receptors in C57Bl/6J Mice at Various Stages of a Depression-Like State

  • G. V. Idova
  • D. V. Jur’ev
  • E. N. Zhukova
  • S. M. Kuznetsova
Immunology and Microbiology
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The development of a depression-like state in C57Bl/6J mice with repeated defeat experience (10 and 20 days) was accompanied by inhibition of the immune response (evaluated from the number of IgM antibody-producing cells). Activation of postsynaptic 5-HT1A receptors with a selective agonist 8-OH-DPAT (1.0 mg/kg) in these animals had no effect on the immune reaction. In mice without the experience of confrontations, stimulation of postsynaptic receptors caused a decrease in the number of IgM antibody-producing cells at the peak of the immune response induced by sheep erythrocytes (5 × 108 cells). However, the count of these cells remained unchanged in mice with a depression-like state (irrespective of the stage of disorder). Activation of presynaptic 5-HT1A receptors with 8-OH-DPAT (0.1 mg/kg) in control animals and mice with 10-day defeat experience was followed by immune stimulation. These changes were not observed in mice with a depression-like state caused by 20-day social stress.

Key Words

depression-like state serotoninergic system pre- and postsynaptic serotonin 5-HT1A receptors immune response 
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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • G. V. Idova
    • 1
  • D. V. Jur’ev
    • 1
  • E. N. Zhukova
    • 1
  • S. M. Kuznetsova
    • 1
  1. 1.Laboratory of Mechanisms of Neurochemical ModulationInstitute of Physiology, Siberian Division of the Russian Academy of Medical SciencesNovosibirskRussia

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