Bulletin of Experimental Biology and Medicine

, Volume 151, Issue 2, pp 223–226

Association of Cold Receptor TRPM8 Gene Polymorphism with Blood Lipid Indices and Anthropometric Parameters in Shorians

  • T. A. Potapova
  • N. S. Yudin
  • I. V. Pilipenko
  • V. F. Kobsev
  • A. G. Romashchenko
  • E. V. Shakhtshneider
  • M. Yu. Ogarkov
  • M. I. Voevoda
Article

DOI: 10.1007/s10517-011-1294-z

Cite this article as:
Potapova, T.A., Yudin, N.S., Pilipenko, I.V. et al. Bull Exp Biol Med (2011) 151: 223. doi:10.1007/s10517-011-1294-z

We analyzed single nucleotide polymorphisms of the cold receptor TRPM8 gene as genetic markers of blood serum lipid indices in Shorians. Associations were found between rs11562975 (L250L) TRPM8 gene mononucleotide polymorphism with total cholesterol and LDL cholesterol and between rs28901637 (P249P) and HDL cholesterol. No associations of P249P and L250L with triglyceride level were found. L250L polymorphism was associated with anthropometric parameters characterizing lipid metabolism (hip and waist circumferences). The TRPM8 gene is likely to be involved in the regulation of lipid metabolism.

Key Words

TRPM8 gene genotypes association cholesterol anthropometric indices 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • T. A. Potapova
    • 1
  • N. S. Yudin
    • 1
  • I. V. Pilipenko
    • 1
  • V. F. Kobsev
    • 1
  • A. G. Romashchenko
    • 1
  • E. V. Shakhtshneider
    • 2
  • M. Yu. Ogarkov
    • 2
  • M. I. Voevoda
    • 2
  1. 1.Institute of Cytology and GeneticsSiberian Division of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Institute of TherapySiberian Division of the Russian of Russian Academy of Medical SciencesNovosibirskRussia

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