Psychoimmunomodulatory Effect of Phenotropil in Animals with Immune Stress

  • M. A. SamotruevaEmail author
  • I. N. Tyurenkov
  • D. L. Teplyi
  • T. K. Serezhnikova
  • E. B. Khlebtsova

We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, orientation, and exploratory activities were reduced, while anxiety increased in animals with immune stress. Phenotropil exhibited the psychoimmunomodulatory effect under these conditions, which manifested in prevention of anxiety and fear response, increase in horizontal locomotion and exploratory behavior, and improvement of immunoreactivity.

Key Words

phenotropil lipopolysaccharide immune stress psychoimmunomodulation 


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© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • M. A. Samotrueva
    • 1
    • 2
    Email author
  • I. N. Tyurenkov
    • 3
  • D. L. Teplyi
    • 4
  • T. K. Serezhnikova
    • 1
    • 2
  • E. B. Khlebtsova
    • 1
    • 2
  1. 1.Department of Pharmacognosy with the Course of Pharmaceutical Technology and BiotechnologyAstrakhanRussia
  2. 2.Astrakhan State Medical AcademyRussian Ministry of HealthAstrakhanRussia
  3. 3.Department of Pharmacology and Biopharmacy, Faculty of Post-training Medical EducationVolgograd State Medical University, Russian Ministry of HealthVolgogradRussia
  4. 4.Department for Physiology and Morphology of Humans and AnimalsAstrakhan State UniversityAstrakhanRussia

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