Bulletin of Experimental Biology and Medicine

, Volume 150, Issue 4, pp 468–470 | Cite as

Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging

  • V. O. Polyakova
  • N. S. Linkova
  • S. A. Pichugin

Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and long-living individuals its intensity decreases.

Key Words

pineal gland aging apoptosis cell proliferation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. N. Anisimov, Uspekhi Gerontol., 2, 74–81 (1998).Google Scholar
  2. 2.
    N. D. Goncharova, V. Kh. Khavinson, B. A. Lapin, Pineal Gland and Age-Specifi c Pathology (Mechanisms and Management) [in Russian], Saint-Petersburg (2007).Google Scholar
  3. 3.
    O. V. Korkushko, V. Kh. Khavinson, V. B. Shatilo, Pineal Gland. Approaches for Correction in Aging [in Russian], Saint-Petersburg (2006).Google Scholar
  4. 4.
    M. A. Pal’tsev, I. M. Kvetnoy, Manual for Neuroimmunoendocrinology [in Russian], Moscow (2008).Google Scholar
  5. 5.
    V. Kh. Khavinson, V. G. Morozov, Epiphysis and Thymus Pep tides in Regulation of Aging [in Russian], Saint-Petersburg (2001).Google Scholar
  6. 6.
    V. Kh. Khavinson, N. D. Yakovleva, V. V. Popuchiev, et al., Bull. Exper. Biol., 131, No. 1, 98–103 (2001).Google Scholar
  7. 7.
    W. C. Bushell, Ann. N.Y. Acad. Sci., 1057, 28–49 (2006).CrossRefGoogle Scholar
  8. 8.
    V. Kh. Khavinson, V. V.Malinin, Gerontological aspects of genome peptide regulation, Basel (2005).Google Scholar
  9. 9.
    C. Schomerus, H. W. Korf, Ann. N.Y. Acad. Sci., 1057, 327–383 (2006).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. O. Polyakova
    • 1
  • N. S. Linkova
    • 1
  • S. A. Pichugin
    • 1
  1. 1.Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical SciencesSaint-PetersburgRussia

Personalised recommendations