Bulletin of Experimental Biology and Medicine

, Volume 150, Issue 4, pp 468–470 | Cite as

Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging

  • V. O. Polyakova
  • N. S. Linkova
  • S. A. Pichugin
Article

Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and long-living individuals its intensity decreases.

Key Words

pineal gland aging apoptosis cell proliferation 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • V. O. Polyakova
    • 1
  • N. S. Linkova
    • 1
  • S. A. Pichugin
    • 1
  1. 1.Saint-Petersburg Institute of Bioregulation and Gerontology, North-West Division, Russian Academy of Medical SciencesSaint-PetersburgRussia

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