Bulletin of Experimental Biology and Medicine

, Volume 150, Issue 1, pp 149–152 | Cite as

Morphofunctional Characteristics of Syncytiotrophoblast and Content of Heat Shock Protein 70 in It during Exacerbation of Herpesvirus Infection in Pregnant Women

  • M. T. Lutsenko
  • N. N. Dorofienko
  • I. A. Andrievskaya
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)

Exacerbation of herpesvirus infection during pregnancy is associated with damage to syncytiotrophoblast infl icted by herpesvirus either directly or via TNF-α (due to contact of NK lymphocytes with villus surface). A sharp decrease in the content of heat shock protein with a molecular weight of 70 Da and activation of caspase-3 were noted in placenta homogenate. This leads to disturbances in syncytiotrophoblast cytosol structure and increase in the relative content of apoptotic nuclei.

Key Words

herpes syncytiotrophoblast heat shock protein with a molecular weight of 70 Da (HSP-70) caspase-3 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • M. T. Lutsenko
    • 1
  • N. N. Dorofienko
    • 1
  • I. A. Andrievskaya
    • 1
  1. 1.Far-Eastern Research Center of Physiology and Pathology of RespirationSiberian Division of the Russian Academy of Medical SciencesBlagoveshchenskRussia

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