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Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats with Stress Ulcers

  • T. M. Falalyeyeva
  • G. E. Samonina
  • T. V. Beregovaya
  • L. A. Andreeva
  • E. V. Dvorshchenko
General Pathology and Pathophysiology

Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect. We conclude that glyprolines hold much promise as pharmaceutical products, which can be used in gastroenterological practice for the prevention and therapy of ulcer disease of the stomach and duodenum.

Key Words

glyprolines stress gastric mucosa lipid peroxidation antioxidant defense enzymes 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • T. M. Falalyeyeva
    • 2
  • G. E. Samonina
    • 1
  • T. V. Beregovaya
    • 2
  • L. A. Andreeva
    • 3
  • E. V. Dvorshchenko
    • 2
  1. 1.Department of Human and Animal Physiology, Biological FacultyM. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Department of Pharmaceutical Physiology, Biological FacultyT. G. Shevchenko Kiev National UniversityMoscowRussia
  3. 3.Institute of Molecular Genetics, Russian Academy of SciencesMoscowRussia

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