Bulletin of Experimental Biology and Medicine

, Volume 148, Issue 6, pp 856–858 | Cite as

Effect of Deprenyl on Free Radical Oxidation in Rat Brain during Immobilization Stress

  • V. E. Tseilikman
  • A. I. Sinitsky
  • K. A. Poyarkov
  • E. V. Vojdaev

Rarely repeated episodes of 1-h immobilization in rats were accompanied by an increase in the content of molecular products of lipid peroxidation and decrease in the amount of oxidatively modifi ed proteins. Monoamine oxidase B inhibitor deprenyl prevented the poststress activation of lipid peroxidation.

Key Words

stress monoamine oxidase B lipid peroxidation protein oxidation deprenyl 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    I. A. Volchegorskii, I. I. Dolgushin, O. L. Kolesnikov, and V. E. Tseilikman, Experimental Modeling and Laboratory Study of Adaptive Reactions in the Organism [in Russian], Chelyabinsk (2000).Google Scholar
  2. 2.
    I. A. Volchegorskii, R. I. Lifshits, A. G. Nalimov, and B. G. Yarovinskii, Vopr. Med. Khimii, No. 1, 127-131 (1989).Google Scholar
  3. 3.
    I. A. Volchegorskii, N. V. Malinovskaya, O. V. Shumeleva, and S. E. Shemyakov, Byull. Eksp. Biol. Med., 144, No. 8, 159-169 (2007).Google Scholar
  4. 4.
    I. A. Volchegorskii, N. A. Skoboleva, and R. I. Lifshits, Vopr. Med. Khimii, No 1, 86-89 (1991).Google Scholar
  5. 5.
    I. A. Volchegorskii, S. E. Shemyakov, I. B. Telesheva, et al., Fiziol. Chel., 31, No. 2, 108-105 (2005).Google Scholar
  6. 6.
    I. A. Volchegorskii, S. E. Shemyakov, V. V. Turygin, and N. V. Malinovskaya, Byull. Eksp. Biol. Med., 132, No. 8, 174 (2001).Google Scholar
  7. 7.
    E. I. Gusev and V. I. Skvortsov, Cerebral Ischemia [in Russian], Moscow (2001).Google Scholar
  8. 8.
    E. E. Dubinina, S. O. Burmistrov, D. A. Khodov, and I. G. Porotov, Vopr. Med. Khimii, 41, No. 1, 24-26 (1995).PubMedGoogle Scholar
  9. 9.
    E. I. L’vovskaya, I. A. Volchegorskii, S. E. Shemyakov, and R. I. Lifshits, Ibid., 31, No. 4, 92-94 (1991).Google Scholar
  10. 10.
    V. E. Tseilikman, I. A. Volchegorskii, O. B. Tseilikman, et al., Ros. Fiziol. Zh., 91, No. 4, 394-398 (2005).Google Scholar
  11. 11.
    S. Knollema, W. Aukema, H. Hom, et al., Stroke, 26, No. 10, 1883-1887 (1995).PubMedGoogle Scholar
  12. 12.
    M. Sano, C. Ernesto, R. G. Thomas, et al., N. Engl. J. Med., 336, No. 17, 1216-1222 (1997).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • V. E. Tseilikman
    • 1
  • A. I. Sinitsky
    • 1
  • K. A. Poyarkov
    • 1
  • E. V. Vojdaev
    • 1
  1. 1.Chelyabinsk State Medical AcademyRussian Ministry of HealthChelyabinskRussia

Personalised recommendations