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Interaction of Afobazole with σ1-Receptors

  • S. B. Seredenin
  • T. A. Antipova
  • M. V. Voronin
  • S. Yu. Kurchashova
  • A. N. Kuimov
Pharmacology and Toxicology

In vitro radioligand assay revealed interaction of afobazole with σ1-receptors (Ki=5.9 × 10—6 M). Translocation of σ1-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10—8 M.

Key Words

afobazole σ1-receptor radioligand binding receptor translocation 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • S. B. Seredenin
    • 1
  • T. A. Antipova
    • 1
  • M. V. Voronin
    • 1
  • S. Yu. Kurchashova
    • 2
  • A. N. Kuimov
    • 2
  1. 1.V. V. Zakusov Institute of PharmacologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.A. N. Belozerskii Institute of Physicochemical BiologyM. V. Lomonosov Moscow State UniversityMoscowRussia

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