Activation of α-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release

  • V. G. Lelyanova
  • D. Thomson
  • R. R. Ribchester
  • E. A. Tonevitsky
  • Y. A. Ushkaryov
Biophysics and Biochemistry

The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes only splash release lasting over many hours. Thus, activation of α-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.

Key Words

neuromuscular transmission acetylcholine release latrophilin latrotoxin 

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • V. G. Lelyanova
    • 1
  • D. Thomson
    • 2
  • R. R. Ribchester
    • 2
  • E. A. Tonevitsky
    • 3
  • Y. A. Ushkaryov
    • 1
  1. 1.Department of Cell and Molecular BiologyImperial CollegeLondonU.K.
  2. 2.Department of Neurosciences of Edinburg UniversityEdinburghU.K.
  3. 3.Russian Research Institute of Sport and Physical EducationMoscowRussia

Personalised recommendations