Activation of α-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release
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The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes only splash release lasting over many hours. Thus, activation of α-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.
Key Wordsneuromuscular transmission acetylcholine release latrophilin latrotoxin
- 7.Y. Ushkaryov, A. Rohou, and S. Siguta, Handb. Exp. Pharmacol., No. 184, 171-206 (2008).Google Scholar