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Changes in CREB (SER133) Content and DNA-Binding Activity of Transcriptional Factors in Rat Brain Cells against the Background of Ladasten Exposure

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.

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References

  1. Yu. V. Vakhitova, M. Kh. Salimgareeva, and S. B. Seredenin, Eksper. Klin. Farmakol., 67, No. 2, 12-15 (2004).

    CAS  Google Scholar 

  2. Yu. V. Vakhitova, M. Kh. Salimgareeva, and S. B. Seredenin, Eksper. Klin. Farmakol., 67, No. 3, 7-9 (2004).

    Google Scholar 

  3. Yu. V. Vakhitova, R. S. Yamidanov, V. A. Vakhitov, and S. B. Seredenin, Mol. Biol., 39, No. 2, 279-285 (2005).

    Article  CAS  Google Scholar 

  4. V. S. Kudrin, S. A. Sergeeva, L. M. Krasnykh, et al., Eksper. Klin. Farmakol., 58, No.4, 8-11 (1995).

    CAS  Google Scholar 

  5. N. N. Dewji and C. Do, Brain Res. Mol. Brain Res., 35, Nos. 1-2, 325-328 (1996).

    Article  PubMed  CAS  Google Scholar 

  6. C. A. Dudley, C. Erbel-Sieler, S. J. Estill, et al., Science, 301, 379-383 (2003).

    Article  PubMed  CAS  Google Scholar 

  7. J. A. Garcia, D. Zhang, S. J. Estill, et al., Ibid, 288, 2226-2230 (2000).

    Article  PubMed  CAS  Google Scholar 

  8. G. A. Gonzalez, P. Menzel, J. Leonard, et al., Mol. Cell. Biol., 11, No. 3, 1306-1312 (1991).

    PubMed  CAS  Google Scholar 

  9. B. C. Granadino, C. Perez-Sanchez, and J. Rey-Campos, Current Genomics, 1, 353-382 (2000).

    Article  CAS  Google Scholar 

  10. P. W. Hoffman and J. M. Chernak, Nucleic Acids Res., 23, No. 12, 2229-2235 (1995).

    Article  PubMed  CAS  Google Scholar 

  11. B. E. Lonze and D. D. Ginty, Neuron, 2002, 35, No. 4, 605-623 (2002).

    Article  PubMed  CAS  Google Scholar 

  12. M. G. Mikhaylova, J. V. Vakhitova, R. S. Yamidanov, et al., Neuropharmacology, 53, No. 5, 601-608 (2007).

    Article  PubMed  CAS  Google Scholar 

  13. G. L. Semenza, L. A. Shimoda, and N. R. Prabhakar, Novartis Found Symp., 272, 2-8 (2006).

    Article  PubMed  CAS  Google Scholar 

  14. T. R. Soderling, Trends Biochem. Sci., 24, No. 6, 232-236 (1999).

    Article  PubMed  CAS  Google Scholar 

  15. W. E. Taylor and E. T. Young, Proc. Natl. Acad. Sci. USA, 87, No. 11, 4098-4102 (1990).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Molecular Immunology and Pharmacology, Institute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of Sciences, Ufa, Russia

    M. Kh. Salimgareeva, Yu. V. Vakhitova, R. S. Yamidanov & S. V. Sadovnikov

  2. Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    S. B. Seredenin

Authors
  1. M. Kh. Salimgareeva
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  2. Yu. V. Vakhitova
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  3. R. S. Yamidanov
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  4. S. V. Sadovnikov
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  5. S. B. Seredenin
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Corresponding author

Correspondence to M. Kh. Salimgareeva.

Additional information

Translated from Byulleten’ Experimental’noi Biologii I Meditsiny, Vol. 147, No. 5, pp. 528-531, May, 2009

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Salimgareeva, M.K., Vakhitova, Y.V., Yamidanov, R.S. et al. Changes in CREB (SER133) Content and DNA-Binding Activity of Transcriptional Factors in Rat Brain Cells against the Background of Ladasten Exposure. Bull Exp Biol Med 147, 599–602 (2009). https://doi.org/10.1007/s10517-009-0573-4

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  • DOI: https://doi.org/10.1007/s10517-009-0573-4

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