Bulletin of Experimental Biology and Medicine

, Volume 147, Issue 3, pp 366–370 | Cite as

Expression of Growth Factors in Endotheliocytes in Vascular Malformations

  • K. A. Pavlov
  • E. A. Dubova
  • A. I. Shchyogolev
  • O. D. Mishnyov
Morphology and Pathomorphology

The expression of growth factors and proliferation of endotheliocytes in vascular malformations were studied by immunohistochemical methods. The detected specific features of growth factor expression in the endothelium of venous and arteriovenous malformations seem to reflect the differences in the pathogenesis of these formations. High proliferative activity of the endothelium in angiodysplasias of both types can underlie the disease relapsing.

Key Words

proliferation vascular malformations growth factors endotheliocytes 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. P. Milovanov, Pathomorphology of Angiodysplasias of the Limbs [in Russian], Moscow (1978).Google Scholar
  2. 2.
    O. D. Mishnyov and A. I. Shchyogolev, Angiodysplasias (Congenital Vascular Malformations) [in Russian], Moscow (2008), pp. 34–53.Google Scholar
  3. 3.
    Y. G. Chen and J. Massague, J. Biol. Chem., 274, No. 6, 3672–3677 (1999).PubMedCrossRefGoogle Scholar
  4. 4.
    S. Hiratsuka, Y. Maru, A. Okada, et al., Cancer Res., 61, No. 3, 1207–1213 (2001).PubMedGoogle Scholar
  5. 5.
    M. J. Karkkainen, P. Haiko, K. Sainio, et al., Nat. Immunol., 5, No. 1, 74–80 (2004).PubMedCrossRefGoogle Scholar
  6. 6.
    T. Koizumi, T. Shiraishi, N. Hagihara, et al., Neurosurgery, 50, No. 1, 117–124 (2002).PubMedCrossRefGoogle Scholar
  7. 7.
    L. B. Meijer-Jorna, C. M. van der Loos, O. J. de Boer, et al., J. Clin. Pathol., 60, No. 7, 798–803 (2007).PubMedCrossRefGoogle Scholar
  8. 8.
    M. Murakami, L. T. Nguyen, Z. W. Zhang, et al., J. Clin. Invest., 118, No. 10, 3355–3366 (2008).PubMedCrossRefGoogle Scholar
  9. 9.
    T. Nakamura, Y. Mochizuki, H. Kanetaki, and S. Karda, Biochem. Biophys. Res. Commun., 289, No. 4, 801–806 (2001).PubMedCrossRefGoogle Scholar
  10. 10.
    T. J. Poole, E. B. Finkelstein, and C. M. Cox, Dev. Dyn., 220, No. 1, 1–17 (2001).PubMedCrossRefGoogle Scholar
  11. 11.
    M. Presta, P. Dell’Era, S. Mitola, et al., Cytokine Growth Factor Rev., 16, No. 6, 159–178 (2005).PubMedCrossRefGoogle Scholar
  12. 12.
    U. Sure, N. Butz, J. Schlegel, et al., J. Neurosurg., 94, No. 6, 972–977 (2001).PubMedCrossRefGoogle Scholar
  13. 13.
    J. C. Tille and M. S. Pepper, Arterioscler. Thromb. Vasc. Biol., 24, No. 9, 1578–1590 (2004).PubMedCrossRefGoogle Scholar
  14. 14.
    W. Tirakotai, B. Liu-Guan, H. Bertalanffy, et al., Chinese Med. J., 117,1815–1820 (2004).Google Scholar
  15. 15.
    R. Uranishi, N. I. Baev, P. Y. Ng, et al., Neurosurgery, 48, No. 2, 359–367 (2001).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • K. A. Pavlov
    • 1
  • E. A. Dubova
    • 1
  • A. I. Shchyogolev
    • 1
    • 2
  • O. D. Mishnyov
    • 1
    • 2
  1. 1.Department of Pathological AnatomyA. V. Vishnevskii Institute of SurgeryMoscowRussia
  2. 2.Department of Pathological Anatomy, Therapeutic FacultyRussian State Medical UniversityMoscowRussia

Personalised recommendations