Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 147, Issue 3, pp 331–334 | Cite as

Antiarrhythmic Activity of Phytoadaptogens in Short-Term Ischemia-Reperfusion of the Heart and Postinfarction Cardiosclerosis

  • L. N. Maslov
  • Yu. B. Lishmanov
  • A. G. Arbuzov
  • A. V. Krylatov
  • E. V. Budankova
  • Yu. N. Konkovskaya
  • V. N. Burkova
  • E. A. Severova
Pharmacology and Toxicology

A course of treatment (16 mg/kg orally during 5 days) by Aralia mandshurica or Rhodiola rosea extracts reduced the incidence of ischemic and reperfusion ventricular arrhythmias during 10-min ischemia and 10-min reperfusion. Extracts of Eleutherococcus senticosus, Leuzea carthamoides, and Panax ginseng did not change the incidence of ischemic and reperfusion arrhythmias. Chronic treatment by aralia, rhodiola, and eleutherococcus elevated the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. Ginseng and leuzea did not change this parameter in rats with postinfarction cardiosclerosis.

Key Words

adaptogens ischemia reperfusion cardiosclerosis arrhythmia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. G. Arbuzov, A. V. Krylatov, L. N. Maslov, et al., Byull. Eksp. Biol. Med., 142, No. 8, 177–180 (2006).Google Scholar
  2. 2.
    Yu. B. Lishmanov and L. N. Maslov, Opioid Neuropeptides, Stress, and Adaptation Protection of the Heart [in Russian], Tomsk (1994).Google Scholar
  3. 3.
    Yu. B. Lishmanov and L. N. Maslov, Byull. Eksp. Biol. Med., 138, No. 8, 124–131 (2004).CrossRefGoogle Scholar
  4. 4.
    L. A. Maimeskulova and L. N. Maslov, Eksp. Klin. Farmakol., 63, No. 4, 29–31 (2000).PubMedGoogle Scholar
  5. 5.
    L. A. Maimeskulova, L. N. Maslov, Yu. B. Lishmanov, and E. A. Krasnov, Ibid., 60, No. 1, 38–39 (1997).Google Scholar
  6. 6.
    V. I. Metelitsa, Handbook of Clinical Pharmacology of Cardiovascular Drugs [in Russian], Moscow, St. Petersburg (2002).Google Scholar
  7. 7.
    B. Y. Gao, X. J. Li, L. Liu, and B. H. Zhang, Yao Xue Xue Bao, 27, No. 9, 641–644 (1992).PubMedGoogle Scholar
  8. 8.
    S. L. Hale and R. A. Kloner, Am. Heart J., 116, No. 6, Pt. 1, 1508–1513 (1988).PubMedCrossRefGoogle Scholar
  9. 9.
    Y. Liu, M. Yan, T. Wang, et al., Zhongguo Zhong Yao Za Zhi, 15, No. 8, 494–496 (1990).PubMedGoogle Scholar
  10. 10.
    L. N. Maslov, Yu. B. Lishmanov, N. V. Solenkova, et al., Life Sci., 73, No. 7, 947–952 (2003).PubMedCrossRefGoogle Scholar
  11. 11.
    J. Neckar, B. Ostadal, and F. Kolar, Physiol. Res., 53, No. 6, 621–628 (2004).PubMedGoogle Scholar
  12. 12.
    J. E. J. Schultz, Y. Z. Qian, G. J. Gross, and R. C. Kukreja, J. Mol. Cell. Cardiol., 29, No. 3, 1044–1060 (1997).CrossRefGoogle Scholar
  13. 13.
    W. Wu, X. M. Zhang, P. M. Liu, et al., Zhongguo Jao Li Xue Bao, 16, No. 5, 459–463 (1995).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • L. N. Maslov
    • 1
  • Yu. B. Lishmanov
    • 1
  • A. G. Arbuzov
    • 2
  • A. V. Krylatov
    • 1
  • E. V. Budankova
    • 1
  • Yu. N. Konkovskaya
    • 1
  • V. N. Burkova
    • 2
  • E. A. Severova
    • 3
  1. 1.Institute of Cardiology, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesTomskRussia
  2. 2.Biolit FirmTomskRussia
  3. 3.Institute of Cardiology and Visceral Diseases, Ministry of Health of KazakhstanAlmatyKazakhstan

Personalised recommendations